ArticleThe Journal of biological chemistry2018
Identification of a precursor processing protease from the spider
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Enlightening the toxinological dark matter of spider venom enzymes.npj biodiversity · 2024Article
- Venom-gland transcriptomics and venom proteomics of the Tibellus oblongus spider.Scientific data · 2023Article
- Molecular Diversity of Linear Peptides Revealed by Transcriptomic Analysis of the Venom Gland of the SpiderToxins · 2022Article
- Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes.Scientific reports · 2021Article
- Advancing d-amino acid-containing peptide discovery in the metazoan.Biochimica et biophysica acta. Proteins and proteomics · 2021Review
- Linear Peptides-A Combinatorial Innovation in the Venom of Some Modern Spiders.Frontiers in molecular biosciences · 2021Article
- Venomics Approach Reveals a High Proportion ofToxins · 2020Article
- Article
- Article
- Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses.Toxins · 2019Review
- Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in theToxins · 2019Article
- Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spider venom neurotoxins and cytolytic peptides are expressed as elongated precursor peptides, which are post-translationally processed by proteases to yield the active mature peptides. The recognition motifs for these processing proteases, first published more than 10 years ago, include the processing quadruplet motif (PQM) and the inverted processing quadruplet motif (iPQM). However, the identification of the relevant proteases was still pending. Here we describe the purification of a neurotoxin precursor processing protease from the venom of the spider
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