ArticleAJNR. American journal of neuroradiology2018
Better Than Nothing: A Rational Approach for Minimizing the Impact of Outflow Strategy on Cerebrovascular Simulations.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- A Subject-Specific Cerebrovascular CFD Modeling Approach Based on a Multimodal Data-Driven Boundary Calibration Framework: A Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2026Article
- Hemodynamic characteristics and drug deposition in cerebral aneurysm sac.Scientific reports · 2025Article
- Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues.Scientific reports · 2025Article
- Amplification of Secondary Flow at the Initiation Site of Intracranial Sidewall Aneurysms.Cardiovascular engineering and technology · 2025Article
- Investigating the role of blood models in predicting rupture status of intracranial aneurysms.Biomedical physics & engineering express · 2025Article
- Maximum admittance method for cerebrovascular outlet boundary conditions and importance of stenosis severity as a dominant factor on hemodynamics.Scientific reports · 2025Article
- Key influencers in an aneurysmal thrombosis model: A sensitivity analysis and validation study.APL bioengineering · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- Computational fluid dynamics modelling of hemodynamics in aortic aneurysm and dissection: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Estimating flow division in aortic branches of diseased aorta: a method for boundary condition specification in CFD analysis.Frontiers in bioengineering and biotechnology · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Research square · 2024Article
- Comparison of Flow Reduction Efficacy of Nominal and Oversized Flow Diverters Using a Novel Measurement-assisted in Silico Method.Clinical neuroradiology · 2024Article
- Evaluating the accuracy of cerebrovascular computational fluid dynamics modeling through time-resolved experimental validation.Scientific reports · 2024Article
- Image-based hemodynamic simulations for intracranial aneurysms: the impact of complex vasculature.International journal of computer assisted radiology and surgery · 2024Article
- Comparison of computational fluid dynamics with transcranial Doppler ultrasound in response to physiological stimuli.Biomechanics and modeling in mechanobiology · 2024Article
- Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Is Accurate Lumen Segmentation More Important than Outlet Boundary Condition in Image-Based Blood Flow Simulations for Intracranial Aneurysms?Cardiovascular engineering and technology · 2023Article
- Aneurysm Neck Overestimation has a Relatively Modest Impact on Simulated Hemodynamics.Cardiovascular engineering and technology · 2023Article
- Efficacy assessment of superficial temporal artery-middle cerebral artery bypass surgery in treating moyamoya disease from a hemodynamic perspective: a pilot study using computational modeling and perfusion imaging.Acta neurochirurgica · 2023Article
- A matched-pair case control study identifying hemodynamic predictors of cerebral aneurysm growth using computational fluid dynamics.Frontiers in physiology · 2023Article
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4 authors.
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Abstract
background and purposeComputational fluid dynamics simulations of neurovascular diseases are impacted by various modeling assumptions and uncertainties, including outlet boundary conditions. Many studies of intracranial aneurysms, for example, assume zero pressure at all outlets, often the default ("do-nothing") strategy, with no physiological basis. Others divide outflow according to the outlet diameters cubed, nominally based on the more physiological Murray's law but still susceptible to subjective choices about the segmented model extent. Here we demonstrate the limitations and impact of these outflow strategies, against a novel "splitting" method introduced here. MATERIALS AND
methodsWith our method, the segmented lumen is split into its constituent bifurcations, where flow divisions are estimated locally using a power law. Together these provide the global outflow rate boundary conditions. The impact of outflow strategy on flow rates was tested for 70 cases of MCA aneurysm with 0D simulations. The impact on hemodynamic indices used for rupture status assessment was tested for 10 cases with 3D simulations.
resultsDifferences in flow rates among the various strategies were up to 70%, with a non-negligible impact on average and oscillatory wall shear stresses in some cases. Murray-law and splitting methods gave flow rates closest to physiological values reported in the literature; however, only the splitting method was insensitive to arbitrary truncation of the model extent.
conclusionsCerebrovascular simulations can depend strongly on the outflow strategy. The default zero-pressure method should be avoided in favor of Murray-law or splitting methods, the latter being released as an open-source tool to encourage the standardization of outflow strategies.
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