Evidence map›Paper›PMID 29269393›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae.

Michael S Little, Samuel J Pellock, William G Walton, Ashutosh Tripathy, Matthew R Redinbo

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

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  10. Sex, puberty, and the gut microbiome.Reproduction (Cambridge, England) · 2023
    Review
  11. Article
  12. Article
  13. Effect of endocrine disruptors on bacterial virulence.Frontiers in cellular and infection microbiology · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Draft Genome Sequences ofMicrobiology resource announcements · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael S LittleDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
Samuel J PellockDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
William G WaltonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
Ashutosh TripathyDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
Matthew R RedinboDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290; redinbo@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
MOLECULAR AND CELLULAR BIOPHYSICS TRAINING PROGRAMT32GM008570 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A, SLEP, KEVIN C · 1995 to 2022
$5.1M
Improving CPT-11 Efficacy Using Structural BiologyR01CA098468 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2003 to 2018
$3.9M
Microbiome-Targeted Probes to Eliminate Chemotherapy-Induced GI ToxicityR01CA207416 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2016 to 2018
$1.7M
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA098468NCI NIH HHS R01 CA207416NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM008570
6 · The paper itself

Abstract

The gut microbiota harbor diverse β-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjugates and complex carbohydrates. However, only the Enterobacteriaceae family of human gut-associated Proteobacteria maintain a GUS operon under the transcriptional control of a glucuronide repressor, GusR. Despite its potential importance in

Indexed as

Gene Expression Regulation, BacterialAmino Acid SequenceBacterial ProteinsBinding SitesCrystallography, X-RayDNAEnterobacteriaceaeEscherichia coliGastrointestinal MicrobiomeGenes, RegulatorGlucuronic AcidGlucuronidaseHumansMutationOperonSequence Homology, Amino AcidBacterial ProteinsDNAGlucuronic AcidGlucuronidasebiochemistrygut microbiotamolecular biologystructural biologytranscriptional regulation

Identifiers

PMID29269393
PMCPMC5777068
OpenAlexW2779845187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.