ArticleMolecular systems biology2017
From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress.
Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine-learning meta-analysis reveals ethylene as a central component of the molecular core in abiotic stress responses in Arabidopsis.Nature communications · 2025Pooled it
- A pan-genomic perspective: comprehensive dissection of the FIG superfamily unravels its evolution, expansion, and environmental adaptation in wheat.BMC plant biology · 2026Article
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- Comprehensive analysis of morphology, transcriptomics, and metabolomics of banana (Frontiers in plant science · 2025Article
- Real-Time Monitoring of Volatile Organic Compound-Mediated Plant Intercommunication Using Surface-Enhanced Raman Scattering Nanosensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Identification and characterization of the Quinoa AP2/ERF gene family and their expression patterns in response to salt stress.Scientific reports · 2024Article
- A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable elements in soybean.Communications biology · 2024Article
- Transcriptomic analysis reveals candidate genes associated with salinity stress tolerance during the early vegetative stage in fababean genotype, Hassawi-2.Scientific reports · 2023Article
- Genome-wide analysis of the AP2/ERF gene family in Tritipyrum and the response of TtERF_B2-50 in salt-tolerance.BMC genomics · 2023Article
- Two interacting ethylene response factors negatively regulate peach resistance to Lasiodiplodia theobromae.Plant physiology · 2023Article
- A Network-Based Approach for Improving Annotation of Transcription Factor Functions and Binding Sites inGenes · 2023Article
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- Regulation of the regulators: Transcription factors controlling biosynthesis of plant secondary metabolites during biotic stresses and their regulation by miRNAs.Frontiers in plant science · 2023Review
- A tandem CCCH type zinc finger protein gene CpC3H3 from Chimonanthus praecox promotes flowering and enhances drought tolerance in Arabidopsis.BMC plant biology · 2022Article
- Past accomplishments and future challenges of the multi-omics characterization of leaf growth.Plant physiology · 2022Review
- Comparative transcriptomic profiling of peach and nectarine cultivars reveals cultivar-specific responses to chilled postharvest storage.Frontiers in plant science · 2022Article
- Transcriptomic Profiling Provides Molecular Insights Into Hydrogen Peroxide-EnhancedFrontiers in plant science · 2022Article
- To Fight or to Grow: The Balancing Role of Ethylene in Plant Abiotic Stress Responses.Plants (Basel, Switzerland) · 2021Review
- Inheritance of gene expression throughout fruit development in chili pepper.Scientific reports · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have established different mechanisms to cope with environmental fluctuations and accordingly fine-tune their growth and development through the regulation of complex molecular networks. It is largely unknown how the network architectures change and what the key regulators in stress responses and plant growth are. Here, we investigated a complex, highly interconnected network of 20 Arabidopsis transcription factors (TFs) at the basis of leaf growth inhibition upon mild osmotic stress. We tracked the dynamic behavior of the stress-responsive TFs over time, showing the rapid induction following stress treatment, specifically in growing leaves. The connections between the TFs were uncovered using inducible overexpression lines and were validated with transient expression assays. This study resulted in the identification of a core network, composed of ERF6, ERF8, ERF9, ERF59, and ERF98, which is responsible for most transcriptional connections. The analyses highlight the biological function of this core network in environmental adaptation and its redundancy. Finally, a phenotypic analysis of loss-of-function and gain-of-function lines of the transcription factors established multiple connections between the stress-responsive network and leaf growth.
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