Evidence map›Paper›PMID 29269377›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice.

Elizabeth K Duperret, Aspen Trautz, Dylan Ammons, Alfredo Perales-Puchalt, Megan C Wise, Jian Yan, Charles Reed, David B Weiner

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  9. Targeting Fibrosis in Arthritis Using mRNA Vaccine-Based Approach.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  19. The fibroinflammatory response in cancer.Nature reviews. Cancer · 2025
    Review
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elizabeth K DuperretVaccine Center, The Wistar Institute, Philadelphia, Pennsylvania.
Aspen TrautzVaccine Center, The Wistar Institute, Philadelphia, Pennsylvania.
Dylan AmmonsVaccine Center, The Wistar Institute, Philadelphia, Pennsylvania.
Alfredo Perales-PuchaltVaccine Center, The Wistar Institute, Philadelphia, Pennsylvania.
Megan C WiseInovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.
Jian YanInovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.
Charles ReedInovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.
David B WeinerVaccine Center, The Wistar Institute, Philadelphia, Pennsylvania. dweiner@wistar.org.
The Wistar Institute · USInovio Pharmaceuticals (United States) · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Nan Zhang · 1985 to 2026
$75.9M
Targeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1M
Targeting hyaluronan in the tumor microenvironment to improve DNA vaccine immunotherapyF32CA213795 · NCI · WISTAR INSTITUTE · PI DUPERRET, ELIZABETH KENNEDY · 2017 to 2018
$94k
NCI NIH HHS F32 CA213795NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA174523
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cancer VaccinesGelatinasesImmunotherapy, ActiveMembrane ProteinsNeoplasmsVaccines, DNAAnimalsAntigens, NeoplasmCD8-Positive T-LymphocytesCell Line, TumorConsensus SequenceEndopeptidasesFemaleFibroblast Activation Protein AlphaHumansLymphocytes, Tumor-InfiltratingAntigens, NeoplasmCancer VaccinesEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsSerine EndopeptidasesVaccines, DNA

Identifiers

PMID29269377
PMCPMC5844837
OpenAlexW2777276783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.