ReviewBrain research bulletin2018
The dynamic nature of fear engrams in the basolateral amygdala.
Review in Brain research bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Chronic stress enhances threat responding and impacts fear extinction.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells.Nature communications · 2025Article
- A neurally constrained computational model of context-dependent fear extinction recall and relapse.Communications biology · 2025Article
- Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025Review
- Neural patterns differentiate traumatic from sad autobiographical memories in PTSD.Nature neuroscience · 2023Article
- Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease.Hippocampus · 2023Review
- Social reactivation of fear engrams enhances memory recall.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Prioritization of social information by the basolateral amygdala in rats.Neurobiology of learning and memory · 2021Article
- Retrorubral field is a hub for diverse threat and aversive outcome signals.Current biology : CB · 2021Article
- Covert capture and attenuation of a hippocampus-dependent fear memory.Nature neuroscience · 2021Article
- The neural, behavioral, and epidemiological underpinnings of comorbid alcohol use disorder and post-traumatic stress disorder.International review of neurobiology · 2021Article
- Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction.Nature communications · 2020Article
- In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.Molecular brain · 2018Article
- Functional Neuronal Topography: A Statistical Approach to Micro Mapping Neuronal Location.Frontiers in neural circuits · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Great progress has been made in our understanding of how so-called memory engrams in the brain enable the storage and retrieval of memories. This has led to the realization that across the lifetime of an animal, the spatial and temporal properties of a memory engram are not fixed, but instead are subjected to dynamic modifications that can be both dependent and independent on additional experiences. The dynamic nature of engrams is especially relevant in the case of fear memories, whose contributions to an animal's evolutionary fitness depend on a delicate balance of stability and flexibility. Though fear memories have the potential to last a lifetime, their expression also needs to be properly tuned to prevent maladaptive behavior, such as seen in patients with post-traumatic stress disorder. To achieve this balance, fear engrams are subjected to complex spatiotemporal dynamics, making them informative examples of the "dynamic engram". In this review, we discuss the current understanding of the dynamic nature of fear engrams in the basolateral amygdala, a brain region that plays a central role in fear memory encoding and expression. We propose that this understanding can be further advanced by studying how fast dynamics, such as oscillatory circuit activity, support the storage and retrieval of fear engrams that can be stable over long time intervals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.