Evidence map›Paper›PMID 29269264›Full record

ReviewDevelopmental and comparative immunology2018

Peptidoglycan recognition proteins in hematophagous arthropods.

Jingwen Wang, Xiumei Song, Mengfei Wang

Abstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jingwen WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China. Electronic address: jingwenwang@fudan.edu.cn.
Xiumei SongMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China.
Mengfei WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China.

Funding

Influence of gut microbiota on vector competence of disease transmitting insectsR01AI129819 · NIAID · FUDAN UNIVERSITY · PI WANG, JINGWEN · 2017 to 2021
$730k
NIAID NIH HHS R01 AI129819
6 · The paper itself

Abstract

Hematophagous arthropods are medically important disease vectors that transmit a variety of pathogens. Unlike mammals that employ both innate and adaptive immunity to clear invading pathogens, these vectors rely mainly on an innate immune system to combat pathogens. Peptidoglycan recognition proteins (PGRPs) are important components of innate immune signaling pathways and are responsible for recognizing microbe-associated molecular patterns (MAMPs), thus regulating host immune interactions with both harmful and helpful microbes. Here we review a number of recent studies in different vectors that address the function of PGRPs in immune regulation. Further, we discuss the variation of PGRPs between vectors and Drosophila.

Indexed as

AnimalsArthropodsCarrier ProteinsDisease VectorsDrosophilaImmunity, InnateImmunomodulationInsect ProteinsPathogen-Associated Molecular Pattern MoleculesPeptidoglycanReceptors, Pattern RecognitionSignal TransductionCarrier ProteinsInsect ProteinsPathogen-Associated Molecular Pattern MoleculesPeptidoglycanpeptidoglycan recognition proteinReceptors, Pattern RecognitionInnate immunityMosquitoPeptidoglycan recognition proteinTicksTsetse flyVectors

Identifiers

PMID29269264
PMCPMC5889321

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.