Evidence map›Paper›PMID 29269038›Full record

SynthesisClinical radiology2018

Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy.

F Yu, D S Barron, B Tantiwongkosi, M Fox, P Fox

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

F YuDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA. Electronic address: frankfy21@gmail.com.
D S BarronDepartment of Psychiatry, Yale School of Medicine, 333 Cedar St., New Haven, CT 06510, USA.
B TantiwongkosiDepartment of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7800, San Antonio, TX 78229, USA.
M FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229, USA.
P FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · USMassachusetts General Hospital · USYale University · US

Funding

Quantification of Thalamic Atrophy and Connectivity in Medial Temporal Lobe EpileF31NS083160 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BARRON, DANIEL S. · 2013 to 2014
$33k
NINDS NIH HHS F31 NS083160
6 · The paper itself

Abstract

aimTo characterise the meta-analytical functional connectivity patterns in progressive supranuclear palsy (PSP) and compare them to idiopathic Parkinson's disease (IPD). MATERIALS AND

methodsIt was previously reported that PSP and IPD showed distinct regions of brain atrophy based on voxel-based morphometry (VBM) meta-analysis. Using these regions as seeds, healthy control data were referenced to create and statistically compare meta-analytical functional connectivity maps of PSP and IPD.

resultsSome overlap was noted between the two diseases, including within the thalamus, striatum, and prefrontal cortex; however, the PSP seeds demonstrated more extensive functional co-activity throughout the brain, particularly within the midbrain, precentral gyrus, parietal cortex, basal ganglia, and cerebellum.

conclusionThese findings may help guide future longitudinal studies in the development of new functional imaging biomarkers for diagnosis and assessing treatment response.

Indexed as

BrainBrain MappingHumansMagnetic Resonance ImagingParkinson DiseaseSupranuclear Palsy, Progressive

Identifiers

PMID29269038
PMCPMC10596737
OpenAlexW2778101089

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.