ArticleHealth and quality of life outcomes2017
Individual diseases or clustering of health conditions? Association between multiple chronic diseases and health-related quality of life in adults.
Article in Health and quality of life outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Multimorbidity and health related quality of life in midlife - a longitudinal study from Northern Finland Birth Cohort 1966.Scandinavian journal of primary health care · 2026Article
- Impact of multimorbidity on change in quality of life in a multi-ethnic Asian population: a longitudinal study.Health and quality of life outcomes · 2026Article
- Health-related quality of life among healthcare workers: a comparative analysis using regression, conditional tree and forests.BMC public health · 2025Article
- Chronic disease clusters and health-related quality of life among individuals with musculoskeletal pain: a Northern Finland Birth Cohort 1966 study.Family practice · 2025Article
- Cardiovascular Disease Multimorbidity and Decreased Health-Related Quality of Life in Haiti: A Cross-Sectional Study.Journal of the American Heart Association · 2025Observational
- Network analysis of demographics, dietary habits and health-related quality of life among northern Chinese population.BMJ public health · 2025Article
- Patient Experience with Chronic Refractory Gout and Its Impact on Health-Related Quality of Life: Literature Review and Qualitative Analysis.Rheumatology and therapy · 2024Article
- The impact of chronic diseases on the health-related quality of life of middle-aged and older adults: the role of physical activity and degree of digitization.BMC public health · 2024Article
- Effects of Community Assets on Major Health Conditions in England: A Data Analytic Approach.Healthcare (Basel, Switzerland) · 2024Article
- Long-term functional outcomes in polytrauma: a fundamentally new approach is needed in prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Impact of medical-nursing combined policy pilot on hospitalization frequency of middle-aged and older patients with chronic diseases: a quasi-experimental study based on China Health and Retirement Longitudinal Study.Frontiers in public health · 2024Article
- Prevalence and patterns of multimorbidity among linguistic groups of patients receiving home care in Ontario: a retrospective cohort study.BMC geriatrics · 2023Article
- Multimorbidity and adverse longitudinal outcomes among patients attending chronic outpatient medical care in Bahir Dar, Northwest Ethiopia.Frontiers in medicine · 2023Article
- Multimorbidity and health-related quality of life among patients attending chronic outpatient medical care in Bahir Dar, Northwest Ethiopia: The application of partial proportional odds model.PLOS global public health · 2022Article
- Multiple comorbid conditions and healthcare resource utilization among adult patients with hyperkalemia: A retrospective observational cohort study using association rule mining.Journal of multimorbidity and comorbidity · 2022Article
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- Interactions of Comorbidity and Five Simple Environmental Unhealthy Habits Concerning Physical and Mental Quality of Life in the Clinical Setting.International journal of environmental research and public health · 2021Article
- Article
- Exercise Training for Patients With Severe Aortic Stenosis in a Convalescent Rehabilitation Ward - A Retrospective Cohort Study.Circulation reports · 2021Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic diseases are highly prevalent and cluster in individuals (multimorbidity). This study investigated the association between multimorbidity and Health-Related Quality of Life (HRQoL), assessing the combination of chronic diseases highly correlated with this outcome.
methodsWe conducted a household survey in 2015 in a random sample of 2912 South Australian adults (48.9 ± 18.1 years; 50.9% females), obtaining information on sociodemographics, lifestyle, and 17 chronic conditions clustered in four different groups (metabolic, cardiovascular, gastrointestinal, and musculoskeletal). Information on physical (PCS) and mental components scores (MCS) of HRQoL were assessed using the SF-12 questionnaire. Multivariable linear regression models considering individual diseases (mutually adjusted) and clusters within- and between-groups were used to test the associations.
resultsOnly 41% of the sample was negative for all the investigated diseases. The most prevalent conditions were osteoarthritis, obesity and hypertension, which affected one in every four individuals. PCS was markedly lower among those reporting stroke, heart failure, and osteoarthritis, but they were not associated with MCS. Direct-trend relationships were observed between the number of chronic conditions (clusters within- and between-groups) and PCS, but not with MCS. The strongest association with PCS was for musculoskeletal conditions (difference between those affected by 2+ conditions and those free of these conditions -6.7 95%CI -8.5;-5.4), and lower PCS were observed in any combination of clusters between-group including musculoskeletal diseases.
conclusionIn the context of multimorbidity, musculoskeletal diseases are a key determinant group of PCS, amplifying the association of other chronic conditions on physical but not on mental health.
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