Evidence map›Paper›PMID 29268752›Full record

ArticleJournal of translational medicine2017

Prostate cancer small non-coding RNA transcriptome in Arabs.

Jingxuan Shan, Khalid Al-Rumaihi, Karim Chouchane, Issam Al-Bozom, Danny Rabah, Karim Farhat, Lotfi Chouchane

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Reference Genes for qPCR-Based miRNA Expression Profiling in 14 Human Tissues.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jingxuan ShanLaboratory of Genetic Medicine and Immunology, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar.ORCID 0000-0003-0667-6733
Khalid Al-RumaihiDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.
Karim ChouchaneFaculty of Medicine and Surgery, Universita Cattolica del Sacro Cuore, Rome, Italy.
Issam Al-BozomDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Danny RabahDepartment of Surgery, Cancer Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Karim FarhatDepartment of Surgery, Cancer Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Lotfi ChouchaneLaboratory of Genetic Medicine and Immunology, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar. loc2008@qatar-med.cornell.edu.
Hamad Medical Corporation · QAKing Saud University · SAWeill Cornell Medical College in Qatar · QAUniversità Cattolica del Sacro Cuore · IT

Funding

Weill Cornell Medicine-Qatar BMRP
6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is a complex disorder resulting from the combined effects of multiple environmental and genetic factors. Small non-coding RNAs (sRNAs), particularly microRNAs (miRNAs), regulate several cellular processes and have an important role in many human malignancies including PCa. We assessed the sRNA profiles associated with PCa in Arabs, a population that has rarely been studied.

methodsWe used next generation sequencing technology to obtain the entire sRNA transcriptome of primary prostate tumor formalin-fixed paraffin-embedded tissues, and their paired non-tumor tissues, collected from Bedouin patients (Qatari and Saudi). The miRNA and the target gene expression were evaluated by real-time quantitative PCR. miRNA KEGG pathway and miRNA target genes were subsequently analyzed by starBase and TargetScan software.

resultsDifferent expression patterns of several sRNA and miRNA editing were revealed between PCa tumor and their paired non-tumor tissues. Our study identified four miRNAs that are strongly associated with prostate cancer, which have not been reported previously. Differentially expressed miRNAs significantly affect various biological pathways, such as cell cycle, endocytosis, adherence junction and pathways involved in cancer. Prediction of potential targets for the identified miRNAs indicates the overexpression of KRAS, BCL2 and down-regulation of PTEN in PCa tumor tissues.

conclusionThese miRNAs, newly associated with prostate cancer, may represent not only markers for the increased risk of PCa in Arabs, but may also reflect the clinical and pathological diversity as well as the ethno-specific heterogeneity of prostate cancer.

Indexed as

ArabsCluster AnalysisGene Expression ProfilingGene Expression Regulation, NeoplasticGene LibraryHigh-Throughput Nucleotide SequencingHumansMaleMicroRNAsProstatic NeoplasmsRNA EditingRNA, MessengerRNA, UntranslatedTranscriptomeMicroRNAsRNA, MessengerRNA, UntranslatedArabsmiRNAmiRNA editingProstate cancerSmall RNA transcriptome

Identifiers

PMID29268752
PMCPMC5740966
OpenAlexW2778801751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.