Evidence map›Paper›PMID 29268608›Full record

ArticleACS infectious diseases2018

Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.

Kris M White, Pablo Abreu, Hui Wang, Paul D De Jesus, Balaji Manicassamy, Adolfo García-Sastre, Sumit K Chanda, Robert J DeVita, Megan L Shaw

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Progress of Influenza Viruses and Inhibitors.Current medicinal chemistry · 2025
    Review
  4. Article
  5. Article
  6. Antiviral potential of nanoparticles for the treatment of Coronavirus infections.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Review
  7. Review
  8. Review
  9. Article
  10. Anno 2021: Which antivirals for the coming decade?Annual reports in medicinal chemistry · 2021
    Article
  11. An overview of functional nanoparticles as novel emerging antiviral therapeutic agents.Materials science & engineering. C, Materials for biological applications · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kris M WhiteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
Pablo AbreuDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
Hui Wang
Paul D De Jesus
Balaji ManicassamyDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
Sumit K Chanda
Robert J DeVita
Megan L ShawDepartment of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.ORCID 0000-0002-1267-0891
Icahn School of Medicine at Mount Sinai · US

Funding

Virus CoreU19AI106754 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALBRECHT, RANDY A. · 2013 to 2017
$26.0M
NOVEL CELLULAR AND VIRAL TARGETS FOR ANTI-INFLUENZA VIRUS DRUGSU01AI074539 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PALESE, PETER · 2007 to 2011
$7.4M
Discovery and validation of pan-influenza antiviralsR56AI139015 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHANDA, SUMIT K, SHAW, MEGAN LOUISE · 2018 to 2018
$749k
Host-targeted antivirals for influenza and other respiratory virus infectionsR21AI102169 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAW, MEGAN LOUISE · 2012 to 2013
$463k
NIAID NIH HHS HHSN272201400008CNIAID NIH HHS R21 AI102169NIAID NIH HHS R56 AI139015NIAID NIH HHS U01 AI074539NIAID NIH HHS U19 AI106754
6 · The paper itself

Abstract

S119 was a top hit from an ultrahigh throughput screen performed to identify novel inhibitors of influenza virus replication. It showed a potent antiviral effect (50% inhibitory concentration, IC

Indexed as

AnimalsAntiviral AgentsBetainfluenzavirusCell LineDrug SynergismGene Expression Regulation, ViralHumansInfluenza A virusMicrobial Sensitivity TestsMolecular StructureOseltamivirProtein AggregatesProtein BindingViral Core ProteinsVirus InternalizationVirus ReplicationAntiviral AgentsOseltamivirProtein AggregatesViral Core Proteinsaggregationantiviralinfluenzanucleoproteinnucleozin

Identifiers

PMID29268608
PMCPMC6145453
OpenAlexW2778165104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.