ArticleAsian-Australasian journal of animal sciences2018
Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds.
Article in Asian-Australasian journal of animal sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 30 citations in OpenAlex.
- Genome-Wide Transcriptome Profiling Reveals the Mechanisms Underlying Hepatic Metabolism under Different Raising Systems in Yak.Animals : an open access journal from MDPI · 2024Article
- Transcriptomic Analysis Reveals Differentially Expressed Circular RNAs Associated with Fecundity in the Sheep Hypothalamus with Different FecB Genotypes.Animals : an open access journal from MDPI · 2024Article
- Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.International journal of molecular sciences · 2022Article
- Identification and characterization of circular RNAs in association with the feed efficiency in Hu lambs.BMC genomics · 2022Article
- Circular RNA screening identifies circMYLK4 as a regulator of fast/slow myofibers in porcine skeletal muscles.Molecular genetics and genomics : MGG · 2022Article
- A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication.mBio · 2021Article
- Comprehensive analysis of differentially expressed circRNAs and ceRNA regulatory network in porcine skeletal muscle.BMC genomics · 2021Article
- Systematic identification and characterization of circular RNAs involved in flag leaf senescence of rice.Planta · 2021Article
- Dynamic Expression and Regulatory Network of Circular RNA for Abdominal Preadipocytes Differentiation in Chicken (Frontiers in cell and developmental biology · 2021Article
- circTAF8 Regulates Myoblast Development and Associated Carcass Traits in Chicken.Frontiers in genetics · 2021Article
- Pituitary-Derived Circular RNAs Expression and Regulatory Network Prediction During the Onset of Puberty in Landrace × Yorkshire Crossbred Pigs.Frontiers in genetics · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAn experiment was conducted to identify and characterize the circular RNA expression and metabolic characteristics in the liver of Jinhua pigs and Landrace pigs.
methodsThree Jinhua pigs and three Landrace pigs respectively at 70-day were slaughtered to collect the liver tissue samples. Immediately after slaughter, blood samples were taken to detect serum biochemical indicators. Total RNA extracted from liver tissue samples were used to prepare the library and then sequence on HiSeq 2500. Bioinformatic methods were employed to analyze sequence data to identify the circRNAs and predict the potential roles of differentially expressed circRNAs between the two breeds.
resultsSignificant differences in physiological and biochemical traits were observed between growing Jinhua and Landrace pigs. We identified 84,864 circRNA candidates in two breeds and 366 circRNAs were detected as significantly differentially expressed. Their host genes are involved in lipid biosynthetic and metabolic processes according to the gene ontology analysis and associated with metabolic pathways.
conclusionOur research represents the first description of circRNA profiles in the porcine liver from two divergent phenotype pigs. The predicted miRNA-circRNA interaction provides important basis for miRNA-circRNA relationships in the porcine liver. These data expand the repertories of porcine circRNA and are conducive to understanding the possible molecular mechanisms involved in miRNA and circRNA. Our study provides basic data for further research of the biological functions of circRNAs in the porcine liver.
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