Evidence map›Paper›PMID 29268571›Full record

ArticleAsian-Australasian journal of animal sciences2018

Effects of dietary supplementation of lipid-coated zinc oxide on intestinal mucosal morphology and expression of the genes associated with growth and immune function in weanling pigs.

Young Min Song, Myeong Hyeon Kim, Ha Na Kim, Insurk Jang, Jeong Hee Han, Giselle Ann Fontamillas, Chul Young Lee, Byung-Chul Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian-Australasian journal of animal sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Young Min SongDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Myeong Hyeon KimDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Ha Na KimDepartment of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Insurk JangDepartment of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Jeong Hee HanCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea.
Giselle Ann FontamillasGraduate School of International Agricultural Technology, and Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea.
Chul Young LeeDepartment of Animal Resources Technology, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.
Byung-Chul ParkGraduate School of International Agricultural Technology, and Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea.ORCID 0000-0003-1489-8678
Gyeongnam National University of Science and Technology · KRSeoul National University of Science and Technology · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study was conducted to investigate the effects of a lipid-coated zinc oxide (ZnO) supplement Shield Zn (SZ) at the sub-pharmacological concentration on intestinal morphology and gene expression in weanling pigs, with an aim to gain insights into the mechanism of actions for SZ.

methodsForty 22-day-old weanling pigs were fed a nursery diet supplemented with 100 or 2,500 mg Zn/kg with uncoated ZnO (negative control [NC] or positive control [PC], respectively), 100, 200, or 400 mg Zn/kg with SZ for 14 days and their intestinal tissues were taken for histological and molecular biological examinations. The villus height (VH) and crypt depth (CD) of the intestinal mucosa were measured microscopically following preparation of the tissue specimen; expression of the genes associated with growth and immune function was determined using the real-time quantitative polymerase chain reaction.

resultsThere was no difference in daily gain, gain:feed, and diarrhea score between the SZ group and either of NC and PC. The VH and VH:CD ratio were less for the SZ group vs NC in the jejunum and duodenum, respectively (p<0.05). The jejunal mucosal mRNA levels of insulin-like growth factor (IGF-I) and interleukin (IL)-10 regressed and tended to regress (p = 0.053) on the SZ concentration with a positive coefficient, respectively, whereas the IL-6 mRNA level regressed on the SZ concentration with a negative coefficient. The mRNA levels of IGF-I, zonula occludens protein-1, tumor necrosis factor-α, IL-6, and IL-10 did not differ between the SZ group and either of NC and PC; the occludin and transforming growth factor-β1 mRNA levels were lower for the SZ group than for PC.

conclusionThe present results are interpreted to suggest that dietary ZnO provided by SZ may play a role in intestinal mucosal growth and immune function by modulating the expression of

Indexed as

Gene ExpressionImmunityIntestineMorphologyPost-weaning PigZinc Oxide

Identifiers

PMID29268571
PMCPMC5838346
OpenAlexW2777463598

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.