Evidence map›Paper›PMID 29268106›Full record

ReviewThe Journal of nutritional biochemistry2018

Food components with antifibrotic activity and implications in prevention of liver disease.

Minkyung Bae, Young-Ki Park, Ji-Young Lee

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  14. The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Minkyung BaeDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Young-Ki ParkDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Ji-Young LeeDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA; Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea. Electronic address: ji-young.lee@uconn.edu.
University of Connecticut · US

Funding

Nutritional Transcriptomics Approach for the Role of Astaxanthin in Liver FibrosisR01DK108254 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI LEE, JI-YOUNG · 2015 to 2018
$1.5M
NIDDK NIH HHS R01 DK108254
6 · The paper itself

Abstract

Increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in parallel with the obesity epidemic has been a major public health concern. NAFLD is the most common chronic liver disease in the United States, ranging from fatty liver to steatohepatitis, fibrosis and cirrhosis in the liver. In response to chronic liver injury, fibrogenesis in the liver occurs as a protective response; however, prolonged and dysregulated fibrogenesis can lead to liver fibrosis, which can further progress to cirrhosis and eventually hepatocellular carcinoma. Interplay of hepatocytes, macrophages and hepatic stellate cells (HSCs) in the hepatic inflammatory and oxidative milieu is critical for the development of NAFLD. In particular, HSCs play a major role in the production of extracellular matrix proteins. Studies have demonstrated that bioactive food components and natural products, including astaxanthin, curcumin, blueberry, silymarin, coffee, vitamin C, vitamin E, vitamin D, resveratrol, quercetin and epigallocatechin-3-gallate, have antifibrotic effects in the liver. This review summarizes current knowledge of the mechanistic insight into the antifibrotic actions of the aforementioned bioactive food components.

Indexed as

FoodBlueberry PlantsCoffeeCurcuminHepatic Stellate CellsHepatocytesHumansLiver CirrhosisMacrophagesNon-alcoholic Fatty Liver DiseaseOxidative StressResveratrolVitaminsXanthophyllsastaxanthineCoffeeCurcuminResveratrolVitaminsXanthophyllsAntifibrotic food componentsHepatic stellate cellsLiver diseaseLiver fibrosisNAFLD

Identifiers

PMID29268106
PMCPMC5936673
OpenAlexW2770646078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.