ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Is grip strength a marker for cognitive function, neurodegeneration, and resilience?GeroScience · 2026Article
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- Long-Term Association of Cardiovascular Risk Burden With Dementia Risk: The Role of Life-Course Confounders in an Analysis of Cumulative and Specific Factors.Journal of the American Heart Association · 2026Article
- The Association Between Social Determinants of Health and Alzheimer Disease Blood Biomarkers in Midlife.medRxiv : the preprint server for health sciences · 2026Article
- Accelerating real-world prediction and research in Alzheimer's: The M3AD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cardiorespiratory fitness is associated with cerebral oxygen extraction in Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Racial and ethnic disparities in childhood cardiovascular health: evidence of the role of social disadvantage from NHANES 2013-2018.BMC medicine · 2025Article
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
- Dementia Prevalence in the CARhES Cohort: Importance of Socioeconomic Level.Journal of clinical medicine · 2025Article
- Regional Differences in Dementia Incidence Among US Veterans.JAMA neurology · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Relationship between Serum Neurotransmitters and Cognitive Impairment in Adults with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Association between life's simple 7 (LS7) and arthritis: the mediating role of body fat percentage (BFP).Lipids in health and disease · 2024Article
- Associations between AHA's Life's Essential 8 and cognition in midlife and older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: The UK Biobank study.Brain, behavior, and immunity · 2024Article
- Cardiovascular Health, Race, and Decline in Cognitive Function in Midlife Women: The Study of Women's Health Across the Nation.Journal of the American Heart Association · 2024Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
introductionThe aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites.
methodsMidlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. We used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change.
resultsHigher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline. Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks. DISCUSSION: Better midlife CVH was associated with higher midlife and reduced decline in cognitive function 20 years later. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. Our findings suggest that improved midlife CVH may promote enduring cognitive health.
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Registered trials
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