Evidence map›Paper›PMID 29268037›Full record

SynthesisThe American journal of sports medicine2018

The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment.

Xiao Chen, Ian A Jones, Caron Park, C Thomas Vangsness

3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 134 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 18 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06040203 narecruitingnot on this mapstarted 2023, after this paper: background citation

Leukocyte-rich PRP or Leukocyte-free PRP vs Placebo in the Treatment of Epicondylitis: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2023 to 2027Enrolled240ConditionsTennis ElbowArmsInjection of autologous leukocyte rich platelet rich plasma (LR-PRP), Injection of autologous leukocyte poor platelet rich plasma (LP-PRP), Placebo (saline solution)
NCT06422390 withdrawnnot on this mapstarted 2025, after this paper: background citation

Platelet - Rich Plasma Injections for Rotator Cuff Tears

TypeobservationalSponsorScripps ClinicRan2025 to 2025Enrolled0ConditionsRotator Cuff TearsArmsPlatelet - Rich Plasma
NCT06846593 naterminatednot on this mapstarted 2024, after this paper: background citation

The Comparison and Combination of Semiconductor Embedded Therapeutic Arm Sleeves and Platelet-Rich Plasma With Adipose Stem Cell (PRP+ASC) Injections for the Treatment of ECRB Tendinopathy (Lateral Epicondylitis): A Randomized, Double-Blinded, Placebo-Controlled Prospective Clinical Trial

TypeinterventionalSponsorINCREDIWEAR HOLDINGS, INC.Ran2024 to 2026Enrolled5ConditionsECRB TendinopathyArmsSemiconductor Embedded Therapeutic Arm Sleeves, Placebo Arm Sleeves, Platelet-Rich Plasma with Adipose Stem Cell (PRP+ASC) Injections
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 18 syntheses or guidelines pooled it, 282 citations in OpenAlex.

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  2. Academic Influence and Industry Funding in Platelet-Rich Plasma Injections: Coauthorship Network Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
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  6. Platelet-rich plasma in chronic Achilles tendinopathy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiao ChenDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ian A JonesDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Caron ParkSouthern California Clinical and Translational Science Institute, Los Angeles, California, USA.
C Thomas VangsnessDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · USSouthern California Clinical and Translational Science Institute · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

backgroundThere has been a surge in high-level studies investigating platelet-rich plasma (PRP) for tendon and ligament injuries. A number of meta-analyses have been published, but few studies have focused exclusively on tendon and ligament injuries. PURPOSE: To perform a meta-analysis assessing the ability of PRP to reduce pain in patients with tendon and ligament injuries. STUDY

designSystematic review and meta-analysis.

methodsThis study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of the literature was carried out in April 2017 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Only level 1 studies were included. Platelet and leukocyte count, injection volume, kit used, participant age/sex, comparator, and activating agent used were recorded. The short-term and long-term efficacy of PRP was assessed using the visual analog scale (VAS) to measure pain intensity. Injury subgroups (rotator cuff, tendinopathy, anterior cruciate ligament, and lateral epicondylitis) were evaluated. Funnel plots and the Egger test were used to screen for publication bias, and sensitivity analysis was performed to evaluate the effect of potential outliers by removing studies one at a time.

resultsThirty-seven articles were included in this review, 21 (1031 participants) of which could be included in the quantitative analysis. The majority of studies published investigated rotator cuff injuries (38.1%) or lateral epicondylitis (38.1%). Seventeen studies (844 participants) reported short-term VAS data, and 14 studies (771 participants) reported long-term VAS data. Overall, long-term follow-up results showed significantly less pain in the PRP group compared with the control group (weighted mean difference [WMD], -0.84; 95% CI, -1.23 to -0.44; P < .01). Patients treated with PRP for rotator cuff injuries (WMD, -0.53; 95% CI, -0.98 to -0.09; P = .02) and lateral epicondylitis (WMD, -1.39; 95% CI, -2.49 to -0.29; P = .01) reported significantly less pain in the long term. Substantial heterogeneity was reported at baseline ( I

conclusionThis review shows that PRP may reduce pain associated with lateral epicondylitis and rotator cuff injuries.

Indexed as

Platelet-Rich PlasmaAnterior Cruciate LigamentAnterior Cruciate Ligament InjuriesHumansPainRotator CuffRotator Cuff InjuriesTendinopathyTennis ElbowTreatment OutcomeVisual Analog ScaleAchilles tendinopathyanterior cruciate ligamentbiologicsinjection therapylateral epicondylitismeta-analysispatellar tendonplatelet-rich plasmaPRProtator cuffsystematic reviewtendinopathy

Identifiers

PMID29268037
PMCPMC6339617
OpenAlexW2777077585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.