Evidence map›Paper›PMID 29267586›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2017

The magnitude of syphilis: from prevalence to vertical transmission.

Luciane Rodrigues Pedreira de Cerqueira, Denise L M Monteiro, Stella R Taquette, Nádia C P Rodrigues, Alexandre J B Trajano, Flavio Monteiro de Souza, Bianca De Melo Araújo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Infections and Pregnancy: Effects on Maternal and Child Health.Frontiers in cellular and infection microbiology · 2022
    Review
  5. Notes on syphilis vaccine development.Frontiers in immunology · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Alternative Treatments for Syphilis During Pregnancy.Sexually transmitted diseases · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luciane Rodrigues Pedreira de CerqueiraUniversidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto, Núcleo Perinatal, Rio de Janeiro, Rio de Janeiro, Brazil.
Denise L M MonteiroUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Stella R TaquetteUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Nádia C P RodriguesUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Alexandre J B TrajanoUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Flavio Monteiro de SouzaUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Bianca De Melo AraújoUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, Rio de Janeiro, Brazil.
Universidade do Estado do Rio de Janeiro · BRHospital Universitário Pedro Ernesto · BRUniversidade Unigranrio · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn 2013, the World Health Organization (WHO) reported that 1.9 million pregnant women were infected with syphilis worldwide, of which 66.5% had adverse fetal effects in cases of untreated syphilis. Congenital syphilis contributes significantly to infant mortality, accounting for 305,000 perinatal deaths worldwide annually.

aimTo estimate the prevalence of syphilis in parturients, the incidence of congenital syphilis and the vertical transmission rate. MATERIAL AND

methodsa cross-sectional study with data collected from 2041 parturients who had undergone treatment between 2012 and 2014 in the maternity section of the Pedro Ernesto Hospital of the State University of Rio de Janeiro, in the metropolitan area of Rio de Janeiro. The inclusion criterion was positive VDRL and treponemal test in a hospital environment.

resultsthe prevalence of syphilis in pregnant women was 4.1% in 2012, 3.1% in 2013 and 5% in 2014, with official reporting of 15.6%, 25.0% and 48.1%, respectively. The incidence of congenital syphilis (CS) was 22/1,000 in live births (LB) in 2012; 17/1,000 LB in 2013 and 44.8/1,000 LB in 2014. CS underreporting during the period was 6.7%. Vertical transmission occurred in 65.8% of infants from infected mothers. It was concluded that, in 34.6% of the CS cases, maternal VDRL titers were = 1/4.

conclusionResults demonstrate the magnitude of the disease, fragility of the reporting system in the assessment of the actual prevalence, impact on perinatal outcomes, and they are a warning about the real situation of syphilis, which is still underestimated in the State.

Indexed as

BrazilCross-Sectional StudiesFemaleHumansIncidenceInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPrevalenceSyphilisSyphilis, Congenital

Identifiers

PMID29267586
PMCPMC5738763
OpenAlexW2777201261

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.