Evidence map›Paper›PMID 29267515›Full record

Observational studySao Paulo medical journal = Revista paulista de medicina

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study.

Rayana Taques Posselt, Vinícius Nicolelli Coelho, Danieli Cristina Pigozzo, Marcela Idalia Guerrer, Marília da Cruz Fagundes, Renato Nisihara, Thelma Larocca Skare

Open access · diamondFull text readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Graves' Disease in Children: An Update.Clinical medicine insights. Endocrinology and diabetes · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rayana Taques PosseltMedical Student, Medicine Department, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.
Vinícius Nicolelli CoelhoMedical Student, Medicine Department, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.
Danieli Cristina PigozzoMD. Attending Physician, Medicine Department, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.
Marcela Idalia GuerrerMD. Attending Physician, Medicine Department, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.
Marília da Cruz FagundesMD. Attending Physician, Medicine Department, Faculdade Evangélica do Paraná, Curitiba (PR), Brazil.
Renato NisiharaPhD. Professor, Medicine Department, Faculdade Evangélica do Paraná and Universidade Positivo, Curitiba (PR), Brazil.
Thelma Larocca SkarePhD. Rheumatologist and Professor, Medicine Department, Rheumatology Unit, Hospital Universitário Evangélico de Curitiba (HUEC), Curitiba (PR), Brazil.
Faculdade Evangélica do Paraná · BRHospital Universitário Evangélico de Curitiba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND

settingCross-sectional observational study in a rheumatology unit.

methods301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes.

resultsThere were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed: P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated.

conclusionSLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.

Indexed as

AdultArthritis, RheumatoidAutoantibodiesAutoimmune DiseasesCase-Control StudiesCross-Sectional StudiesDisability EvaluationFemaleHumansIodide PeroxidaseLupus Erythematosus, SystemicMaleMiddle AgedPrevalenceRheumatic DiseasesScleroderma, Systemicanti-thyroglobulinAutoantibodiesIodide Peroxidase

Identifiers

PMID29267515
PMCPMC10016010
OpenAlexW2771613959

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read56
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.