Evidence map›Paper›PMID 29267352›Full record

ArticlePloS one2017

Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients.

Myeong Hee Kim, Yu Ho Lee, Jung-Woo Seo, Haena Moon, Jin Sug Kim, Yang Gyun Kim, Kyung-Hwan Jeong, Ju-Young Moon, Tae Won Lee, Chun-Gyoo Ihm and 5 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. The diagnostic potential of extracellular vesicles in virus-related diseases.Frontiers in cellular and infection microbiology · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Myeong Hee KimDepartment of Laboratory Medicine, Kyung Hee University, Seoul, Korea.
Yu Ho LeeDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Jung-Woo SeoDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Haena MoonDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Jin Sug KimDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Yang Gyun KimDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Kyung-Hwan JeongDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Ju-Young MoonDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Tae Won LeeDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Chun-Gyoo IhmDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
Chan-Duck KimDivision of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Jae Berm ParkDepartment of Surgery, Samsung Medical Center, Seoul, Korea.
Byung Ha ChungDivision of Nephrology, Department of Internal Medicine, College of Medicine, The St. Mary's Hospital of Catholic University of Korea, Seoul, Korea.
Young-Hoon KimDivision of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea.
Sang-Ho LeeDivision of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.ORCID 0000-0001-9915-6221
Kyung Hee University · KRInje University · KRKyungpook National University Hospital · KRSamsung Medical Center · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in the blood among the patients with BK virus nephropathy (BKVN). Urinary exosome was suggested to be a possible source of biomarker for kidney diseases, but it was unknown whether it could contain viral microRNA as well as human microRNAs. The aim of this study was to evaluate whether urinary exosomal BK viral microRNA were expressed during replication and could be used to diagnose BKVN in kidney transplant recipients. MATERIALS AND

methodsIn a cross-sectional multicenter study, we collected and analyzed 458 graft biopsies from 385 kidney transplant recipients. Urine samples were collected at the time of graft biopsy, and microRNAs in urinary exosome were measured once. For 13 patients with BKVN and 67 age, sex-matched kidney transplant recipients, we measured BK viral microRNA B1-5p, 3p and human microRNA-16 in urinary exosomal fraction and compared the diagnostic value with BK viral load in plasma and urine.

resultsPathology proven BKVN was diagnosed in 13 patients (2.8%). High levels of bkv-miR-B1-5p and bkv-miR-B1-3p were shown in all patients with BKVN. Meanwhile, plasma BK viral load assay (cut-off value of ≥ 4.0 log10 copies/mL) showed false negative in 3 cases and urinary BK viral load assay (cut-off value of ≥ 7.0 log10 copies/mL) showed false negative in 1 case among these 13 patients. The receiver operator characteristics curve analysis for bkv-miR-B1-5p and bkv-miR-B1-5p/miR-16 showed excellent discriminative power for the diagnosis of BKVN, with area under the curve values of 0.989 and 0.985, respectively.

conclusionsThis study suggests that urinary exosomal bkv-miR-B1-5p and bkv-miR-B1-5p/miR-16 could be surrogate markers for the diagnosis of BKVN.

Indexed as

Kidney TransplantationAdultBK VirusCross-Sectional StudiesExosomesFemaleHumansKidney DiseasesMaleMicroRNAsMiddle AgedPolyomavirus InfectionsPrevalenceViral LoadMicroRNAs

Identifiers

PMID29267352
PMCPMC5739476
OpenAlexW2777934592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.