ArticleIEEE transactions on bio-medical engineering2018
In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain.
Article in IEEE transactions on bio-medical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Deep Volumetric Super-Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models.Frontiers in oncology · 2023Review
- Fluorescence radial fluctuation enables two-photon super-resolution microscopy.Frontiers in cellular neuroscience · 2023Article
- Super-Resolution Microscopy: Shedding New Light onFrontiers in chemistry · 2021Review
- Tissue Transparency In Vivo.Molecules (Basel, Switzerland) · 2019Review
- Peeking into the sleeping brain: Using in vivo imaging in rodents to understand the relationship between sleep and cognition.Journal of neuroscience methods · 2019Review
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Authors and funding
7 authors.
Funding
Abstract
objectivethis study proposes and evaluates a technique for in vivo deep-tissue superresolution imaging in the light-scattering mouse brain at up to a 3.5 Hz 2-D imaging rate with a 21×21 μm
methodswe combine the deep-tissue penetration and high imaging speed of resonant laser scanning two-photon (2P) microscopy with the superresolution ability of patterned excitation microscopy. Using high-frequency intensity modulation of the scanned two-photon excitation beam, we generate patterned illumination at the imaging plane. Using the principles of structured illumination, the high-frequency components in the collected images are then used to reconstruct images with an approximate twofold increase in optical resolution.
resultsusing our technique, resonant 2P superresolution patterned excitation reconstruction microscopy, we demonstrate our ability to investigate nanoscopic neuronal architecture in the cerebral cortex of the mouse brain at a depth of 120 μm in vivo and 210 μm ex vivo with a resolution of 119 nm. This technique optimizes the combination of speed and depth for improved in vivo imaging in the rodent neocortex.
conclusionthis study demonstrates a potentially useful technique for superresolution in vivo investigations in the rodent brain in deep tissue, creating a platform for investigating nanoscopic neuronal dynamics. SIGNIFICANCE: this technique optimizes the combination of speed and depth for improved superresolution in vivo imaging in the rodent neocortex.
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