Evidence map›Paper›PMID 29266926›Full record

ArticleACS chemical neuroscience2018

A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors.

Matthew R Banghart, Xinyi J He, Bernardo L Sabatini

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. A Chemically Stable Photocaged Noradrenaline.ACS chemical neuroscience · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Chemical tools for the opioids.Molecular and cellular neurosciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Matthew R BanghartDivision of Biological Sciences, Section on Neurobiology , University of California San Diego , La Jolla , California 92093 , United States.ORCID 0000-0001-7248-2932
Xinyi J HeDivision of Biological Sciences, Section on Neurobiology , University of California San Diego , La Jolla , California 92093 , United States.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston , Massachusetts 02115 , United States.
Howard Hughes Medical Institute · USUniversity of California San Diego · US

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Peptide Modulation of Striatal Patch and Matrix SubdivisionsR01MH100568 · NIMH · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2013 to 2017
$2.1M
Regulation of neuron and synapse function by neuropeptidesR01MH085498 · NIMH · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2008 to 2011
$1.3M
Compartment-specific signaling of striatal opioid peptides in reward-guided behaviorR00DA034648 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R. · 2017 to 2019
$747k
Compartment-Specific Signaling Of Striatal Opioid Peptides in Reward-Guided BehavK99DA034648 · NIDA · HARVARD MEDICAL SCHOOL · PI BANGHART, MATTHEW R. · 2013 to 2014
$243k
NIDA NIH HHS K99 DA034648NIDA NIH HHS R00 DA034648NIGMS NIH HHS T32 GM007240NIMH NIH HHS R01 MH085498NIMH NIH HHS R01 MH100568
6 · The paper itself

Abstract

Physiological responses to the opioid neuropeptide enkephalin often involve both mu and delta opioid receptors. To facilitate quantitative studies into opioid signaling, we previously developed a caged [Leu

Indexed as

AnimalsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-EnkephalinsHippocampusNeuronsPotassium ChannelsRats, Sprague-DawleyReceptors, Opioid, deltaReceptors, Opioid, muSynaptic TransmissionEnkephalin, Ala(2)-MePhe(4)-Gly(5)-EnkephalinsPotassium ChannelsReceptors, Opioid, deltaReceptors, Opioid, muCaged compoundsneuropeptidesneurophysiologyopioid receptorspotassium channelssynaptic transmission

Identifiers

PMID29266926
PMCPMC5906201
OpenAlexW2777821340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.