SynthesisJBRA assisted reproduction2018
Is the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta-analysis.
Synthesis in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2019Pooled it
- The outcomes of surrogate pregnancy using donor egg compared to surrogate's egg: a systematic review.Journal of assisted reproduction and genetics · 2026Article
- Maternal and neonatal outcomes in singleton pregnancies conceived using donor oocytes: a retrospective cohort study.Maternal health, neonatology and perinatology · 2025Article
- Article
- Endometrial Aging and Reproductive Decline: The Central Role of Mitochondrial Dysfunction.International journal of molecular sciences · 2025Review
- Amniotic Fluid Embolism in Donor Egg Twin Pregnancy: A Clinical Challenge in Critical Care.Cureus · 2025Article
- Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison.Frontiers in immunology · 2025Article
- Treatment Progress in Diminished Ovarian Reserve: Western and Chinese Medicine.Chinese journal of integrative medicine · 2023Review
- Why Are the Proportions of In-Vitro Fertilisation Interventions for Same Sex Female Couples Increasing?Healthcare (Basel, Switzerland) · 2021Article
- Obstetric and Perinatal Complications Associated with Assisted Reproductive Techniques - Review.Maedica · 2021Article
- Article
- Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan.Frontiers in reproductive health · 2021Review
- Are we looking under the lamp although we know the lost key is somewhere else? Or is it just about the egg?Upsala journal of medical sciences · 2020Article
- Risk of Preeclampsia and Adverse Pregnancy Outcomes after Heterologous Egg Donation: Hypothesizing a Role for Kidney Function and Comorbidity.Journal of clinical medicine · 2019Article
- Maternal and neonatal outcomes associated with trophectoderm biopsy.Fertility and sterility · 2019Observational
- Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes.Medicina (Kaunas, Lithuania) · 2019Article
- Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia.International journal of molecular sciences · 2019Observational
- Transient diabetes insipidus in a post-partum woman with pre-eclampsia associated with residual placental vasopressinase activity.Endocrinology, diabetes & metabolism case reports · 2018Article
- What are the Predictive Factors for Preeclampsia in Oocyte Recipients?Journal of human reproductive sciencesArticle
- Pregnancy Outcomes FollowingIn vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePreeclampsia (PE) occurs in 4.6% of pregnancies worldwide. The social phenomenon of increasing maternal age has raised the demand for donor oocytes. Egg donation has allowed women with poor ovarian reserve, premature ovarian failure, genetic disorders or surgical menopause to get pregnant. Recipients provide a unique model of immune response because of the differences in the genetic makeup of mothers and fetuses. In PE, immune tolerance may be impaired as a result of having non-autologous eggs implanted. Egg donation is a highly successful assisted reproductive technology, despite the significant number of issues arising from the implantation of non-autologous eggs. This study aimed to determine whether there is an association between egg donation and preeclampsia.
methodsA systematic review of the literature available in PubMed and Google Scholar was carried out from January of 1995 to August of 2016 using the terms 'oocyte donation, preeclampsia', 'oocyte donation, in vitro fertilization, preeclampsia', 'oocyte donation, preeclampsia, outcomes pregnancies', 'oocyte donation, obstetric outcome.' Only six retrospective cohort studies met the selection criteria.
resultsThe meta-analysis revealed a statistically significant association between egg donation and onset of preeclampsia (OR 4.50; 95% CI: 3.28-6.19; p<0.0001).
conclusionOocyte donation is associated with increased risk of preeclampsia in singleton pregnancies. Therefore, it is crucial to properly record and assess this finding when egg donation is the chosen assisted reproductive technology to attain pregnancy.
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