Evidence map›Paper›PMID 29266831›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Inferior long-term allograft and patient outcomes among recipients of offspring living donor kidneys.

J B Cohen, L Owei, D L Sawinski, P M Porrett

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. It's All Relative: Donor-Recipient Relationships, Disease Heritability, and Kidney Transplant Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
  5. Review
  6. Review
  7. Memory B Cells in Pregnancy Sensitization.Frontiers in immunology · 2021
    Review
  8. Article
  9. Article
  10. Better graft outcomes from offspring donor kidneys among living donor kidney transplant recipients in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J B CohenRenal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
L OweiPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
D L SawinskiRenal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
P M PorrettPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USHospital of the University of Pennsylvania · US

Funding

Management of hypertension in obesity: Antihypertensive class effects, blood pressure control, and renal and cardiac outcomesK23HL133843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COHEN, JORDANA B. · 2016 to 2020
$945k
NHLBI NIH HHS K23 HL133843
6 · The paper itself

Abstract

While offspring-to-parent living donor kidney transplantations may represent an ideal donor-recipient combination to optimize long-term transplantation outcomes, the sex-specific long-term success of these transplantations remains unclear. We hypothesize that allograft and recipient survivals in offspring-to-parent living donor kidney transplantation differ between men and women due to donor-specific alloimmunization during pregnancy. We retrospectively analyzed long-term allograft and patient survival among men and women who received an offspring living donor kidney compared with those who received other haplotype-matched living donor kidneys. Based on multivariable Cox proportional hazards modeling of Organ Procurement and Transplantation Network data from 2001 to 2015, we found that both men and women who received offspring living donor kidneys had significantly increased mortality compared with recipients who received nonoffspring living donor kidneys. While male recipients of any living donor kidney had greater risk of mortality and allograft failure than female recipients, there was no significant difference in all-cause allograft failure or mortality in male versus female recipients of offspring living donor kidney transplantations. Our analysis demonstrated no significant interaction between recipient sex and donor offspring status. We conclude that nonoffspring living donors should be considered whenever feasible for both men and women with multiple donor options.

Indexed as

Postoperative ComplicationsAdultAgedAllograftsFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHLA AntigensHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleHLA Antigensclinical research/practiceepidemiologygendergraft survivalkidney transplantation: living donorkidney transplantation/nephrologypregnancy

Identifiers

PMID29266831
PMCPMC6013327
OpenAlexW2776809219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.