ArticleEuropean journal of pain (London, England)2018
Expectations about the effectiveness of pain- and itch-relieving medication administered via different routes.
Article in European journal of pain (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Nocebo expectations rather than placebo expectations affect topical pain relief: A randomized clinical trial.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Trial
- Acute Pain Management Following Mandibular Third Molar Exodontia: A Bibliometric Analysis of Randomized Controlled Trials.International dental journal · 2025Article
- Development and validation of the General attitude towards Medication Questionnaire (GAMQ).BMC psychology · 2024Article
- The roles of expectation, comparator, administration route, and population in open-label placebo effects: a network meta-analysis.Scientific reports · 2023Article
- Individual differences in mental imagery in different modalities and levels of intentionality.Memory & cognition · 2022Article
- Atypical presentation of complex regional pain syndrome: neuropathic itching - A case report.Anesthesia and pain medicine · 2021Article
- Is there a relationship between cannabis use problems, emotion dysregulation, and mental health problems among adults with chronic pain?Psychology, health & medicine · 2020Article
- Anxiety sensitivity and opioid misuse and dependence among trauma-exposed adults with chronic pain.Journal of behavioral medicine · 2020Article
- Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations.Frontiers in psychiatry · 2019Article
- The Knowledge of Contextual Factors as Triggers of Placebo and Nocebo Effects in Patients With Musculoskeletal Pain: Findings From a National Survey.Frontiers in psychiatry · 2019Article
- [Placebo and nocebo effects on itch : Methodological and clinical implications].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlacebo effects on pain have been found to vary in size for different routes of medication administration (e.g. oral vs. injection). This has important implications for both clinical research and practice. To enhance our understanding of these differential placebo effects, research on the underlying expectations about multiple routes and symptoms other than pain is vital.
methodsA cross-sectional, Internet-based survey was conducted in a representative sample of the Dutch population (n = 508). Respondents rated the expected effectiveness of pain- and itch-relieving medication in six forms, representing oral, injection and topical routes of administration.
resultsInjected medication was expected to be most effective for relieving pain, and topical medication for relieving itch. Furthermore, exploratory analyses showed that injections were expected to have the most rapid onset and long-lasting effects, and to be most frightening and expensive, while topical medication was expected to be the safest and the easiest to use, and oral medication was expected to have the most side effects. Higher expected effectiveness was moderately associated with expectations of more rapid onset and long-lasting effects, and better safety and ease of use. Associations of expected effectiveness with respondent characteristics (e.g. medication use and personality characteristics) were statistically small or nonsignificant.
conclusionsExpected effectiveness of medication differed depending on route of administration and targeted symptom. These findings have important implications for the design and interpretation of clinical trials and suggest that medication effects might be enhanced by prescribing medicine via the route that patients expect to be most effective for their complaint. SIGNIFICANCE: Differences in the expected effectiveness of medication depend on the route of administration (oral, injection, topical) and targeted symptom (pain, itch). These findings have important implications for clinical practice and the design and interpretation of clinical trials.
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