ArticleHuman brain mapping2018
Confirmation of a gyral bias in diffusion MRI fiber tractography.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 148 citations in OpenAlex.
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- A reproducible low-dimensional architecture of human white-matter connectivity.Research square · 2026Article
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Microscopy-informed structural connectivity mapping in the in vivo human brain via domain adaptation.bioRxiv : the preprint server for biology · 2026Article
- Bridging Histology and Tractography: First In Vivo Visualization of Short-Range Prefrontal Connections Informed by Primate Tract-Tracing.Human brain mapping · 2026Article
- Altered structural networks and cognitive functioning in long-term survivors of pediatric brain tumors.Neuroimage. Reports · 2026Article
- Data-driven subtyping of Parkinson's disease using MRI: current insights, challenges, and future directions.Frontiers in aging neuroscience · 2026Review
- A subject-specific reversible folding model reveals geometry-driven white-matter organization.bioRxiv : the preprint server for biology · 2025Article
- Mapping Caudolenticular Gray Matter Bridges in the Human Brain Striatum Through Diffusion Magnetic Resonance Imaging and Tractography.Human brain mapping · 2025Article
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- The relationship of white matter tract orientation to vascular geometry in the human brain.Scientific reports · 2025Article
- Imaging the structural connectome with hybrid MRI-microscopy tractography.Medical image analysis · 2025Article
- The scientific value of tractography: accuracy vs usefulness.Brain structure & function · 2025Article
- The relationship of white matter tract orientation to vascular geometry in the human brain.bioRxiv : the preprint server for biology · 2025Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
- Spurious correlations in surface-based functional brain imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Streamline tractography of the fetal brain in utero with machine learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A map of white matter tracts in a lesser ape, the lar gibbon.Brain structure & function · 2024Article
- Assessment of the Depiction of Superficial White Matter Using Ultra-High-Resolution Diffusion MRI.Human brain mapping · 2024Article
- Mapping short association fibre connectivity up to V3 in the human brain in vivo.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Diffusion MRI fiber tractography has been increasingly used to map the structural connectivity of the human brain. However, this technique is not without limitations; for example, there is a growing concern over anatomically correlated bias in tractography findings. In this study, we demonstrate that there is a bias for fiber tracking algorithms to terminate preferentially on gyral crowns, rather than the banks of sulci. We investigate this issue by comparing diffusion MRI (dMRI) tractography with equivalent measures made on myelin-stained histological sections. We begin by investigating the orientation and trajectories of axons near the white matter/gray matter boundary, and the density of axons entering the cortex at different locations along gyral blades. These results are compared with dMRI orientations and tract densities at the same locations, where we find a significant gyral bias in many gyral blades across the brain. This effect is shown for a range of tracking algorithms, both deterministic and probabilistic, and multiple diffusion models, including the diffusion tensor and a high angular resolution diffusion imaging technique. Additionally, the gyral bias occurs for a range of diffusion weightings, and even for very high-resolution datasets. The bias could significantly affect connectivity results using the current generation of tracking algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.