Evidence map›Paper›PMID 29266392›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2018

Short pulse width in subthalamic stimulation in Parkinson's disease: a randomized, double-blind study.

Walid Bouthour, Jennifer Wegrzyk, Shahan Momjian, Julie Péron, Vanessa Fleury, Emilie Tomkova Chaoui, Judit Horvath, Colette Boëx, Christian Lüscher, Pierre R Burkhard and 2 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy of short pulse and conventional deep brain stimulation in Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Walid BouthourDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Jennifer WegrzykDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Shahan MomjianDepartment of Neurosurgery, Geneva University Hospital, Geneva, Switzerland.
Julie PéronDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Vanessa FleuryDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Emilie Tomkova ChaouiDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Judit HorvathDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Colette BoëxDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.ORCID 0000-0002-9374-4791
Christian LüscherDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Pierre R BurkhardDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
Paul KrackDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.
André ZachariaDepartment of Neurology, Geneva University Hospital, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the acute effect of short pulse widths on the therapeutic window in subthalamic nucleus deep brain stimulation in Parkinson's disease.

methodsWe assessed 10 PD patients with STN-DBS at a 60-µs pulse width. We randomly and double-blindedly applied 10- to 50-µs pulse widths. The principal outcome was the therapeutic window (difference between the amplitude thresholds for visible muscle contraction and for best rigidity control). The secondary outcome was the charge per pulse (which reflects the efficiency of the stimulation) needed to control rigidity. Two-way analysis of variance and pairwise t tests were applied.

resultsThe therapeutic window widened when the pulse width shortened (r = -0.45; P < 0.001), and charge per pulse was reduced (P < 0.05).

conclusionsThis randomized, double-blind study showed that shorter pulse widths widen the therapeutic window of STN-DBS in PD without increasing the electrical charge required to obtain the same acute clinical benefit. © 2017 International Parkinson and Movement Disorder Society.

Indexed as

BiophysicsDeep Brain StimulationDouble-Blind MethodFemaleHumansMaleMiddle AgedParkinson DiseaseSeverity of Illness IndexStatistics, NonparametricSubthalamic NucleusTreatment Outcomedeep brain stimulationParkinson's diseasepulse widthrigiditysubthalamic nucleus

Identifiers

PMID29266392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.