ArticleMagnetic resonance in medicine2018
Double diffusion encoding MRI for the clinic.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Microscopic Fractional Anisotropy Detects Cognitive Training-Induced Microstructural Brain Changes.Tomography (Ann Arbor, Mich.) · 2022Trial
- Developing an SNR-efficient tensor-valued diffusion encoding protocol for studying brain microstructural changes in neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Diffusion tensor subspace imaging of double diffusion-encoded MRI delineates small fibers and gray-matter microstructure not visible with single encoding techniques.Magnetic resonance in medicine · 2025Article
- Microstructure-informed brain tissue classification using clustering of quantitative MRI measures.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Hippocampal microscopic fractional anisotropy is reduced in temporal lobe epilepsy.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Identification of diffusion, kurtosis, and propagator MRI markers of Alzheimer's disease pathology in post-mortem human tissue.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Extra-axonal contribution to double diffusion encoding-based pore size estimates in the corticospinal tract.Magma (New York, N.Y.) · 2023Article
- A novel framework for in-vivo diffusion tensor distribution MRI of the human brain.NeuroImage · 2023Article
- Optimal experimental design and estimation for q-space trajectory imaging.Human brain mapping · 2023Article
- Estimation of free water-corrected microscopic fractional anisotropy.Frontiers in neuroscience · 2023Article
- Differentiation of white matter histopathology using b-tensor encoding and machine learning.PloS one · 2023Article
- Diffusion phase-imaging in anisotropic media using non-linear gradients for diffusion encoding.PloS one · 2023Article
- Comparison of two types of microscopic diffusion anisotropy in mouse brain.NMR in biomedicine · 2023Article
- MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan.Magnetic resonance in medicine · 2022Article
- Nonparametric 5D D-RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.NeuroImage · 2022Review
- Recent Advances in Parameter Inference for Diffusion MRI Signal Models.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- Evidence for microscopic kurtosis in neural tissue revealed by correlation tensor MRI.Magnetic resonance in medicine · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
purposeThe purpose of this study is to develop double diffusion encoding (DDE) MRI methods for clinical use. Microscopic diffusion anisotropy measurements from DDE promise greater specificity to changes in tissue microstructure compared with conventional diffusion tensor imaging, but implementation of DDE sequences on whole-body MRI scanners is challenging because of the limited gradient strengths and lengthy acquisition times.
methodsA custom single-refocused DDE sequence was implemented on a 3T whole-body scanner. The DDE gradient orientation scheme and sequence parameters were optimized based on a Gaussian diffusion assumption. Using an optimized 5-min DDE acquisition, microscopic fractional anisotropy (μFA) maps were acquired for the first time in multiple sclerosis patients.
resultsBased on simulations and in vivo human measurements, six parallel and six orthogonal diffusion gradient pairs were found to be the minimum number of diffusion gradient pairs necessary to produce a rotationally invariant measurement of μFA. Simulations showed that optimal precision and accuracy of μFA measurements were obtained using b-values between 1500 and 3000 s/mm
conclusionThe μFA maps can be measured using DDE in a clinical setting and may provide new opportunities for characterizing multiple sclerosis lesions and other types of tissue degeneration. Magn Reson Med 80:507-520, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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