Evidence map›Paper›PMID 29266323›Full record

ArticleMuscle & nerve2018

Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy.

Doris G Leung, Xin Wang, Peter B Barker, John A Carrino, Kathryn R Wagner

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01671865 (Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01671865 active not recruitingnot on this map

Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy

TypeobservationalSponsorHugo W. Moser Research Institute at Kennedy Krieger, Inc.Ran2012 to 2028Enrolled75ConditionsFacioscapulohumeral Muscular Dystrophy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Multiparametric quantitative magnetic resonance imaging of skeletal muscle in CKD.American journal of physiology. Renal physiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Doris G LeungCenter for Genetic Muscle Disorders, Hugo W. Moser Research Institute at Kennedy Krieger Institute, 716 North Broadway, Room 411, Baltimore, Maryland, 21205, USA.ORCID 0000-0002-2558-7798
Xin WangDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Peter B BarkerDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
John A CarrinoDepartment of Radiology and Imaging, Hospital for Special Surgery, New York, New York, USA.
Kathryn R WagnerCenter for Genetic Muscle Disorders, Hugo W. Moser Research Institute at Kennedy Krieger Institute, 716 North Broadway, Room 411, Baltimore, Maryland, 21205, USA.
Kennedy Krieger Institute · USHospital for Special Surgery · USJohns Hopkins University · USUniversity of Nebraska Medical Center · US

Funding

Myogenesis Studies for FSHD BiomarkersU54HD060848 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI EMERSON, CHARLES P. · 2008 to 2017
$16.1M
Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Study of White Matter Development in a Rodent Model of Perinatal Brain InjuryK08NS063956 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI · 2009 to 2013
$897k
Magnetic resonance imaging and spectroscopy biomarkers for facioscapulohumeral muscular dystrophyK23NS091379 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LEUNG, DORIS G · 2015 to 2019
$885k
NCATS NIH HHS KL2 TR001077NICHD NIH HHS U54 HD060848NICHD NIH HHS U54 HD079123NINDS NIH HHS K08 NS063956NINDS NIH HHS K23 NS091379
6 · The paper itself

Abstract

introductionFacioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. This study evaluates the use of proton magnetic resonance spectroscopy (

methodsThirty-six individuals with FSHD and 15 healthy controls underwent multivoxel

resultsThe TMA/creatine (Cr) ratio in individuals with FSHD was reduced compared with controls. The TMA/Cr ratio in the hamstrings also showed a moderate linear correlation with muscle strength. DISCUSSION:

Indexed as

Proton Magnetic Resonance SpectroscopyAdultAgedFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthMuscular Dystrophy, FacioscapulohumeralYoung Adultbiomarkersfacioscapulohumeral muscular dystrophymagnetic resonance spectroscopymetabolite quantificationskeletal muscletrimethylamine

Identifiers

PMID29266323
PMCPMC5951728
OpenAlexW2777539799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.