Evidence map›Paper›PMID 29266291›Full record

ReviewImmunological reviews2017

Building conventions for unconventional lymphocytes.

Lesley Pasman, Dennis L Kasper

Abstract readReview
In one paragraph

Review in Immunological reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Primordial Cells Bridging the Gap Between Innate and Adaptive Immunity.Advances in experimental medicine and biology · 2025
    Review
  3. Review
  4. Natural Killer T-like Cells: Immunobiology and Role in Disease.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lesley PasmanDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Dennis L KasperDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2M
Role of DN T cells in colonic microbiota-immune system maturationF32DK111126 · NIDDK · HARVARD MEDICAL SCHOOL · PI PASMAN, LESLEY · 2017 to 2018
$71k
NIAID NIH HHS U19 AI109764NIDDK NIH HHS F32 DK111126
6 · The paper itself

Abstract

Falling between the classical characteristics of innate immune cells and adaptive T and B cells are a group of lymphocytes termed "unconventional." These cells express antigen-specific T or B cell receptors, but behave with innate characteristics. Well-known members of this group include the gamma-delta T cell and the Natural Killer T cell. Recent literature has greatly expanded scientific knowledge of unconventional lymphocytes, but key questions remain unresolved in the field, including why these cells have been maintained concurrently with conventional innate and adaptive immune cells. Here, we summarize current literature that suggests what their unique purposes may be, including specialized functions with the microbiota and in early development. From the consensus literature, we discuss where we see unconventional lymphocytes fit into the logical organization of the complete immune system.

Indexed as

Adaptive ImmunityAnimalsHumansImmunity, InnateLymphocytesLymphocyte SubsetsMicrobiotaReceptors, Antigen, B-CellReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaReceptors, Antigen, B-CellReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltalymphocytesMAITmicrobiotaNKTunconventionalγδ

Identifiers

PMID29266291
PMCPMC5745033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.