Evidence map›Paper›PMID 29266260›Full record

Trial reportCancer2018

Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial.

L Lee Dupuis, Kara M Kelly, Jeffrey P Krischer, Anne-Marie Langevin, Roy N Tamura, Ping Xu, Lu Chen, E Anders Kolb, Nicole J Ullrich, Olle Jane Z Sahler and 4 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04651608 (Effectiveness of Acupress in The Management of Chemotherapy-Developed Acute Nausea Vomiting Symptoms In Child Oncology Patients), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04651608 nacompletednot on this map

Effectiveness of Acupress in The Management of Chemotherapy-Developed Acute Nausea Vomiting Symptoms In Child Oncology Patients

TypeinterventionalSponsorAkdeniz UniversityRan2017 to 2018Enrolled44ConditionsPediatric Cancer, Nausea With Vomiting Chemotherapy-InducedArmsmanuel acupressure, sea-band acupressure, placebo manuel acupressure, placebo sea-band
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Prevalence and predictors of long-delayed (> 120 h) chemotherapy-induced nausea and vomiting (CINV)-a systematic review and individual patient data meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  10. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

L Lee DupuisDepartment of Pharmacy and Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-7699-1061
Kara M KellyDepartment of Pediatrics, Roswell Park Cancer Institute, Buffalo, New York.
Jeffrey P KrischerHealth Informatics Institute, University of South Florida, Tampa, Florida.
Anne-Marie LangevinDivision of Pediatric Hematology/Oncology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Roy N TamuraHealth Informatics Institute, University of South Florida, Tampa, Florida.
Ping XuHealth Informatics Institute, University of South Florida, Tampa, Florida.
Lu ChenDepartment of Information Sciences, City of Hope, Duarte, California.
E Anders KolbDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Nicole J UllrichDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.
Olle Jane Z SahlerPediatric Hematology/Oncology, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, New York.
Eleanor HendershotPediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Ann StrattonDepartment of Cancer and Blood Disorders, Akron Children's Hospital, Akron, Ohio.
Lillian SungDepartment of Pediatrics, Division of Hematology/Oncology and Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Thomas W McLeanDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
University of South Florida · USUniversity of Toronto · CAAkron Children's Hospital · USAlfred I. duPont Hospital for Children · USCity of Hope · USHarvard University · USRoswell Park Comprehensive Cancer Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Rochester Medical Center · USWake Forest University · US

Funding

Towards a preventive cancer vaccine for children with constitutional mismatch repair deficiencyUG1CA189955 · NCI · PUBLIC HEALTH INSTITUTE · PI BRAD H POLLOCK, Michael E. Roth · 2014 to 2026
$62.5M
Community Clinical Oncology Program Research BaseU10CA095861 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI POLLOCK, BRAD H · 2002 to 2013
$19.5M
NCI NIH HHS U10 CA095861NCI NIH HHS UG1 CA189955
6 · The paper itself

Abstract

backgroundChemotherapy-induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy-induced nausea in adults, but it has not been well studied in children.

methodsIn this multicenter, prospective, randomized, single-blind, sham-controlled trial, the authors compared acute-phase nausea severity in patients ages 4 to 18 years who were receiving highly emetic chemotherapy using standard antiemetic agents combined with acupressure wrist bands, the most common type of acupressure, versus sham bands. Patients wore acupressure or sham bands continuously on each day of chemotherapy and for up to 7 days afterward. Chemotherapy-induced nausea severity in the delayed phase and chemotherapy-induced vomiting control in the acute and delayed phases also were compared.

resultsOf the 187 patients randomized, 165 contributed nausea severity assessments during the acute phase. Acupressure bands did not reduce the severity of chemotherapy-induced nausea in the acute phase (odds ratio [OR], 1.33; 95% confidence limits, 0.89-2.00, in which an OR <1.00 favored acupressure) or in the delayed phase (OR, 1.23; 95% CL, 0.75-2.01). Furthermore, acupressure bands did not improve daily vomiting control during the acute phase (OR, 1.57; 95% CL, 0.95-2.59) or the delayed phase (OR, 0.84; 95% CL, 0.45-1.58). No serious adverse events were reported.

conclusionsAcupressure bands were safe but did not improve chemotherapy-induced nausea or vomiting in pediatric patients who were receiving highly emetic chemotherapy. Cancer 2018;124:1188-96. © 2017 American Cancer Society.

Indexed as

AcupressureAdolescentAntiemeticsAntineoplastic AgentsChildChild, PreschoolCombined Modality TherapyFemaleHumansMaleNauseaNeoplasmsProspective StudiesSeverity of Illness IndexSingle-Blind MethodTreatment OutcomeAntiemeticsAntineoplastic Agentsacupressurechemotherapynauseapediatricssupportive carevomiting

Identifiers

PMID29266260
PMCPMC5839969
OpenAlexW2780524123

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.