Evidence map›Paper›PMID 29265862›Full record

ArticleRehabilitation psychology2017

Using the NIH Toolbox Cognition Battery (NIHTB-CB) in individuals with traumatic brain injury.

David S Tulsky, Noelle E Carlozzi, James Holdnack, Robert K Heaton, Alex Wong, Arielle Goldsmith, Allen W Heinemann

Registry-linked trialAbstract read
In one paragraph

Article in Rehabilitation psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06480838 (Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06480838 recruitingnot on this mapstarted 2023, after this paper: background citation

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2023 to 2029Enrolled130ConditionsTraumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, TBI (Traumatic Brain Injury)
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Test-Retest Reliability and Reliable Change on the NIH Toolbox Cognition Battery.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  19. Minimal Detectable Change for the ImPACT Subtests at Baseline.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David S TulskyCenter for Health Assessment Research and Translation, University of Delaware.
Noelle E CarlozziCenter for Clinical Outcomes, Development and Application (CODA), University of Michigan.
James HoldnackCenter for Health Assessment Research and Translation, University of Delaware.
Robert K HeatonDepartment of Psychiatry, University of California, San Diego.
Alex WongProgram in Occupational Therapy and Department of Neurology, Washington University in St. Louis.ORCID 0000-0002-4423-2685
Arielle GoldsmithCenter for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab.
Allen W HeinemannCenter for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab.

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Blueprint for Neuroscience Research; Office of Behavioral and Social Sciences Research; National Institutes of HealthNational Institute on Disability, Independent Living, and Research RehabilitationNIGMS NIH HHS U54 GM104941NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

PURPOSE/

objectiveThe NIH Toolbox for the Assessment of Neurological Behavior and Function Cognition Battery (NIHTB-CB) is a common data element for use in individuals with traumatic brain injury (TBI). This study evaluates its sensitivity and specificity in distinguishing individuals with complicated mild, moderate, or severe TBI, and provides support for the construct validity of the NIHTB-CB in individuals with TBI. RESEARCH

methodOne hundred eighty-two individuals with TBI (n = 83 complicated mild/moderate; n = 99 severe) completed the NIHTB-CB and neuropsychological criterion measures. Complete data were obtained on 158 participants. A control sample of 158 individuals without known neurological impairment was extracted from the NIHTB-CB normative sample. Multivariate analyses of variance determined the sensitivity of the NIHTB-CB measures to TBI and injury severity (complicated mild/moderate TBI, severe TBI, and controls) on the demographically corrected NIHTB-CB composite scores and seven subtests. A descriptive analysis of the sensitivity of each subtest was conducted. Finally, correlations between NIHTB-CB measures and criterion tests assessed convergent and discriminant validity.

resultsMultivariate analyses indicated that there was a main effect for group (complicated mild/moderate vs. severe vs. controls) for fluid scores in the NIHTB-CB as opposed to only marginally significant results for the verbal scores. Moderate to strong relationships were found between the NIHTB-CB measures and their corresponding neuropsychological measures (convergent validity), whereas much smaller correlations were found between measures of different cognitive domains (discriminant validity).

conclusionsFindings provide evidence of construct validity and the clinical utility of the NIHTB-CB in individuals with TBI. (PsycINFO Database Record

Indexed as

AdultBrain Injuries, TraumaticCognitionCognition DisordersFemaleHumansMaleNational Institutes of Health (U.S.)Neuropsychological TestsPsychometricsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexUnited States

Identifiers

PMID29265862
PMCPMC6462276

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.