Evidence map›Paper›PMID 29265728›Full record

ArticleThe FEBS journal2018

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.

Allison R O'Rourke, Angus Lindsay, Michael D Tarpey, Samantha Yuen, Preston McCourt, D'anna M Nelson, Benjamin J Perrin, David D Thomas, Espen E Spangenburg, Dawn A Lowe and 1 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Essential nucleotide- and protein-dependent functions ofProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Allison R O'RourkeDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Angus LindsayDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Michael D TarpeyDepartment of Physiology, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Samantha YuenDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Preston McCourtDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
D'anna M NelsonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Benjamin J PerrinDepartment of Biology, Indiana University-Purdue University Indianapolis, IN, USA.
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Espen E SpangenburgDepartment of Physiology, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Dawn A LoweDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
James M ErvastiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USEast Carolina University · USIndiana University – Purdue University Indianapolis · US

Funding

Costamere Defects in Muscular DystrophiesR01AR049899 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI ERVASTI, JAMES M · 2005 to 2025
$8.2M
Structural Dynamics of Muscle ContractionR01AR032961 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 1986 to 2018
$8.0M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Use of specific transcription factors to promote limb regeneration capacityP30AR057220 · NIAMS · UNIVERSITY OF MINNESOTA · PI DARABI, RADBOD · 2009 to 2013
$3.0M
BRCA1 is necessary for optimal skeletal muscle functionR01AR066660 · NIAMS · EAST CAROLINA UNIVERSITY · PI SPANGENBURG, ESPEN E · 2015 to 2019
$1.6M
NIAMS NIH HHS P30 AR057220NIAMS NIH HHS R01 AR032961NIAMS NIH HHS R01 AR049899NIAMS NIH HHS R01 AR066660NIA NIH HHS R01 AG031743NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

While α-actin isoforms predominate in adult striated muscle, skeletal muscle-specific knockouts (KOs) of nonmuscle cytoplasmic β

Indexed as

Mitochondrial DynamicsMuscle RelaxationActinsAnimalsCells, CulturedCytoplasmEmbryo, MammalianIn Vitro TechniquesMaleMice, KnockoutMicroscopy, Electron, TransmissionMitochondrial DiseasesMitochondria, LiverMitochondria, MuscleMuscle Fibers, SkeletalMuscle, SkeletalActinsProtein Isoformsisoformsmitochondrial dynamicsβ-actinγ-actin

Identifiers

PMID29265728
PMCPMC5799018
OpenAlexW2775867870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.