ArticleHuman brain mapping2018
Structural connectivity of the amygdala in young adults with autism spectrum disorder.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Pharmacological intervention for irritability, aggression, and self-injury in autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2023Pooled it
- Investigating alexithymia in autism: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2019Pooled it
- Atypical sensory traits and changes in white matter microstructures connected to the amygdala and hippocampus of the autistic brain.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection.Molecular psychiatry · 2026Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Alterations in Amygdala and Hippocampal Volumes in Autism Spectrum Disorder: Meta-analysis.Journal of autism and developmental disorders · 2026Article
- Forensic neuroimaging in childhood abduction, rape and murder case and trial outcome.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- Call to Action: Standardizing Follow-Up Care for Infants Prenatally Exposed to Opioids.Hospital pediatrics · 2025Article
- Oxytocin in neurodevelopmental disorders: Autism spectrum disorder and Prader-Willi syndrome.Pharmacology & therapeutics · 2024Review
- The correlation between brain structure characteristics and emotion regulation ability in children at high risk of autism spectrum disorder.European child & adolescent psychiatry · 2024Article
- Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging.Translational psychiatry · 2024Article
- Modality-specific effects of threat on self-motion perception.BMC biology · 2024Article
- Spherical convolutional neural networks can improve brain microstructure estimation from diffusion MRI data.Frontiers in neuroimaging · 2024Article
- Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity.Translational psychiatry · 2023Article
- White and gray matter correlates of theory of mind in autism: a voxel-based morphometry study.Brain structure & function · 2023Article
- Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders.Life (Basel, Switzerland) · 2023Review
- Volumetric Analysis of Amygdala and Hippocampal Subfields for Infants with Autism.Journal of autism and developmental disorders · 2023Article
- A revisit of the amygdala theory of autism: Twenty years after.Neuropsychologia · 2023Review
- Intrinsic Structural Connectivity of the Default Mode Network and Behavioral Correlates of Executive Function and Social Skills in Youth with Autism Spectrum Disorders.Journal of autism and developmental disorders · 2023Article
- Investigating heterogeneity across autism, ADHD, and typical development using measures of cortical thickness, surface area, cortical/subcortical volume, and structural covariance.Frontiers in child and adolescent psychiatry · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Autism spectrum disorder (ASD) is characterized by impairments in social cognition, a function associated with the amygdala. Subdivisions of the amygdala have been identified which show specificity of structure, connectivity, and function. Little is known about amygdala connectivity in ASD. The aim of this study was to investigate the microstructural properties of amygdala-cortical connections and their association with ASD behaviours, and whether connectivity of specific amygdala subregions is associated with particular ASD traits. The brains of 51 high-functioning young adults (25 with ASD; 26 controls) were scanned using MRI. Amygdala volume was measured, and amygdala-cortical connectivity estimated using probabilistic tractography. An iterative 'winner takes all' algorithm was used to parcellate the amygdala based on its primary cortical connections. Measures of amygdala connectivity were correlated with clinical scores. In comparison with controls, amygdala volume was greater in ASD (F(1,94) = 4.19; p = .04). In white matter (WM) tracts connecting the right amygdala to the right cortex, ASD subjects showed increased mean diffusivity (t = 2.35; p = .05), which correlated with the severity of emotion recognition deficits (rho = -0.53; p = .01). Following amygdala parcellation, in ASD subjects reduced fractional anisotropy in WM connecting the left amygdala to the temporal cortex was associated with with greater attention switching impairment (rho = -0.61; p = .02). This study demonstrates that both amygdala volume and the microstructure of connections between the amygdala and the cortex are altered in ASD. Findings indicate that the microstructure of right amygdala WM tracts are associated with overall ASD severity, but that investigation of amygdala subregions can identify more specific associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.