Evidence map›Paper›PMID 29265373›Full record

ArticleJournal of neurochemistry2018

Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.

Flavio H Beraldo, Valeriy G Ostapchenko, Jason Z Xu, Gianni M Di Guglielmo, Jue Fan, Peter J Nicholls, Marc G Caron, Vania F Prado, Marco A M Prado

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Prion Protein at the Leading Edge: Its Role in Cell Motility.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Flavio H BeraldoDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Valeriy G OstapchenkoDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Jason Z XuRobarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Gianni M Di GuglielmoDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Jue FanDepartment of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Peter J NichollsPsychiatry & Behavioral Sciences, Duke University, Durham, North Carolina, USA.
Marc G CaronDepartment of Cell Biology, Duke University, Durham, North Carolina, USA.
Vania F PradoDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Marco A M PradoDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-3028-5778
Western University · CADuke University · US

Funding

Whole brain multimodal microscopy of an apoptosis reporter mouseR21NS081513 · NINDS · DUKE UNIVERSITY · PI NICHOLLS, PETER JEFF · 2012 to 2013
$424k
CIHRNINDS NIH HHS R21 NS081513
6 · The paper itself

Abstract

Stress-inducible phosphoprotein 1 (STI1) acts as a neuroprotective factor in the ischemic brain and its levels are increased following ischemia. Previous work has suggested that some of these STI1 actions in a stroke model depend on the recruitment of bone marrow-derived stem cells to improve outcomes after ischemic insult. However, STI1 can directly increase neuroprotective signaling in neurons by engaging with the cellular prion protein (PrP

Indexed as

Activin Receptors, Type Ialpha7 Nicotinic Acetylcholine ReceptorAnimalsApoptosisBrain IschemiaCells, CulturedFemaleHeat-Shock ProteinsMaleMiceMice, Inbred C57BLNeuroprotectionPrion ProteinsProtein BindingSignal TransductionActivin Receptors, Type IAcvr1 protein, mousealpha7 Nicotinic Acetylcholine ReceptorHeat-Shock ProteinsPrion ProteinsStip1 protein, mouseALK2prion proteinSTIP1Stress-inducible phosphoprotein 1strokeα7nAChR

Identifiers

PMID29265373
PMCPMC7887631
OpenAlexW2779201813

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.