SynthesisJournal of the American Geriatrics Society2018
Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults.
Synthesis in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update.Drugs & aging · 2023Pooled it
- The role of qualification and quality management in the prescription of antipsychotics and potentially inappropriate medication (PIM) in nursing home residents in Germany: results of the HIOPP-3-iTBX study.Aging clinical and experimental research · 2023Trial
- Reduction of Potentially Inappropriate Medication in the Elderly.Deutsches Arzteblatt international · 2021Trial
- Protocol: Emerging Roles and Care Impacts of Geriatric Pharmacists in Outpatient Multidisciplinary Frailty and Geriatric Syndrome Management: A Systematic Review.Campbell systematic reviews · 2026Review
- Pharmacists' views on potential non-medical prescribing for pharmacists in Sweden: a nationwide survey study.International journal of clinical pharmacy · 2026Article
- Barriers and enablers of elderly care specialists towards deprescribing practices in the nursing homes: a focus group study.BMC health services research · 2025Article
- Identifying predictors of medication-related harm in older populations: a latent class analysis approach.Age and ageing · 2025Article
- Prevalence of key potentially inappropriate drugs use in pediatrics: a cross-sectional study.BMC pediatrics · 2024Observational
- Analyzing the Iatrogenic Triad: Discovering Strategies for Preventing Harm in the Elderly.Turkish journal of pharmaceutical sciences · 2024Article
- Improving medication prescribing-related outcomes for vulnerable elderly in transitions on high-risk medications (IMPROVE-IT HRM): a pilot randomized trial protocol.Pilot and feasibility studies · 2024Article
- Prevalence of urgent hospitalizations caused by adverse drug reactions: a cross-sectional study.Scientific reports · 2024Article
- Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions.Journal of clinical medicine · 2024Article
- Improving ADR reporting in Jordan: a qualitative exploration of pharmacists' perspectives.Frontiers in medicine · 2024Article
- Adverse drug reactions in geriatric psychiatry-retrospective cohort study of a 6-year period.Irish journal of medical science · 2023Article
- Deprescribing trials: A focus on adverse drug withdrawal events.Journal of the American Geriatrics Society · 2022Article
- Article
- Medication use problems among older adults at a primary care: A narrative of literature review.Aging medicine (Milton (N.S.W)) · 2022Review
- Adverse drug reactions in an ageing PopulaTion (ADAPT) study: Prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients.Frontiers in pharmacology · 2022Article
- Feasibility of a pharmacist-facilitated medicines review intervention for community-dwelling Māori older adults.Exploratory research in clinical and social pharmacy · 2021Article
- Adverse drug reactions in older adults: a narrative review of the literature.European geriatric medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesTo examine the effect of interventions to optimize medication use on adverse drug reactions (ADRs) in older adults.
designSystematic review and meta-analysis. EMBASE, PubMed, OVID, Cochrane Library, Clinicaltrials.gov, and Google Scholar were searched through April 30, 2017.
settingRandomized controlled trials.
participantsOlder adults (mean age ≥65) taking medications. MEASUREMENTS: Two authors independently extracted relevant information and assessed studies for risk of bias. Discrepancies were resolved in consensus meetings. The outcomes were any and serious ADRs. Random-effects models were used to combine the results of multiple studies and create summary estimates.
resultsThirteen randomized controlled trials involving 6,198 older adults were included. The studies employed a number of different interventions that were categorized as pharmacist-led interventions (8 studies), other health professional-led interventions (3 studies), a brief educational session (1 study), and a technology intervention (1 study). The intervention group was 21% less likely than the control group to experience any ADR (odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62-0.99). In the six studies that examined serious ADRs, the intervention group was 36% less likely than the control group to experience a serious ADR (OR = 0.64, 95% CI = 0.42-0.98).
conclusionInterventions designed to optimize medication use reduced the risk of any and serious ADRs in older adults. Implementation of these successful interventions in healthcare systems may improve medication safety in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.