Evidence map›Paper›PMID 29264656›Full record

SynthesisClinical oral investigations2018

Conservative surgical treatments for nonsyndromic odontogenic keratocysts: a systematic review and meta-analysis.

Mayara Santos de Castro, Clenivaldo Alves Caixeta, Marina Lara de Carli, Noé Vital Ribeiro Júnior, Marta Miyazawa, Alessandro Antônio Costa Pereira, Felipe Fornias Sperandio, João Adolfo Costa Hanemann

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Review
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  12. Article
  13. Recurrence-free survival and prognostic factors of odontogenic keratocyst: a single-center retrospective cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  14. Article
  15. Protocol for management of odontogenic keratocysts considering recurrence according to treatment methods.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020
    Article
  16. [Effect of decompression combined with curettage and autogenous bone cement implantation on large cysts of the jaw].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Article
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  18. Review
  19. [Techniques for the treatment of keratocyst, review of the literature and case report].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mayara Santos de CastroDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil. maya.castro@outlook.com.
Clenivaldo Alves CaixetaDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Marina Lara de CarliDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Noé Vital Ribeiro JúniorDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Marta MiyazawaDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Alessandro Antônio Costa PereiraDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Felipe Fornias SperandioDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
João Adolfo Costa HanemannDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, 700 Gabriel Monteiro da Silva Street, Alfenas, MG, 37130001, Brazil.
Universidade Federal de Alfenas · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Not applicable - Masters Scholarship
6 · The paper itself

Abstract

objectivesThis manuscript presents a systematic review of the clinicopathologic features and outcomes of conservative surgical treatments for nonsyndromic odontogenic keratocysts (OKCs) and assesses the recurrence rates through a meta-analysis, in order to indicate the best conservative approach. MATERIALS AND

methodsPRISMA guidelines for systematic reviews were followed, and the protocol was registered (PROSPERO/Nr.: CRD42017060964). An electronic search was conducted using the PubMed/MEDLINE, Science Direct, Web of Science, Scopus, and The Cochrane Library databases, and relevant articles were selected based on specific inclusion criteria. The PICOS criteria (Population: nonsyndromic patients of any age with OKC, with histopathological diagnosis and minimum follow-up of 12 months; Intervention and Comparison: marsupialization or decompression with or without enucleation, and enucleation alone; Outcome: recurrence rates; Study design: clinical trials, controlled trials, retrospective studies, and case series containing at least 10 cases of OKC) were employed. A pooled odds ratio (OR) was computed through the Mantel-Haenszel test (M-H) with 95% confidence intervals (CI).

resultsOne thousand nine hundred OKCs were analyzed; the age of the patients varied from 6 to 90 years (mean of 38.6 years); a male to female ratio of 1.57:1 was observed; 74.5% of the lesions occurred in the mandible; 75.7% of OKCs were unilocular; the association with impacted tooth was reported for 344 OKCs; and the mean follow-up was 60.1 months. One thousand three hundred thirty-one OKCs were treated by conservative surgical treatments, and 261 cases (19.8%) presented recurrence. Nonetheless, minor total recurrence rates were observed after decompression followed by enucleation (11.9%) and marsupialization followed by enucleation (17.8%). In contrast, enucleation alone showed a total recurrence rate of 20.8%.

conclusionThe results suggest a significant superiority of success for OKC treatments that use decompression followed by enucleation, instead of an initial enucleation (M-H, OR = 0.48; 95% CI = 0.22 to 1.08; P = 0.0163). CLINICAL RELEVANCE: No consensus exists concerning the best management for OKCs. More aggressive treatments (ostectomy, resection, or use of adjunctive therapies like Carnoy's solution and liquid nitrogen) can have many disadvantages and risks. Therefore, it is necessary to identify the conservative approach for OKCs that results in a lower recurrence rate.

Indexed as

Conservative TreatmentHumansOdontogenic CystsRecurrenceDecompressionEnucleationMarsupializationMeta-analysisOdontogenic keratocystRecurrence

Identifiers

PMID29264656
OpenAlexW2778475256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.