Evidence map›Paper›PMID 29264579›Full record

ArticleAnnals of hepato-biliary-pancreatic surgery2017

Promoter methylation of cysteine dioxygenase type 1: gene silencing and tumorigenesis in hepatocellular carcinoma.

Jung-Il Choi, Eung-Ho Cho, Sang Bum Kim, Ryounggo Kim, Junhye Kwon, Misun Park, Hye-Jin Shin, Han Suk Ryu, Sun-Hoo Park, Kee-Ho Lee

Open access · diamondAbstract read
In one paragraph

Article in Annals of hepato-biliary-pancreatic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jung-Il ChoiDepartment of Surgery, Korea Cancer Center Hospital, Seoul, Korea.
Eung-Ho ChoDepartment of Surgery, Korea Cancer Center Hospital, Seoul, Korea.
Sang Bum KimDepartment of Surgery, Korea Cancer Center Hospital, Seoul, Korea.
Ryounggo KimDepartment of Surgery, Dongnam Institution of Radiological & Medical Sciences, Busan, Korea.
Junhye KwonDepartment of Translational Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Misun ParkDepartment of Translational Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Hye-Jin ShinDepartment of Translational Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Han Suk RyuDepartment of Pathology, Seoul National University Hospital, Seoul, Korea.
Sun-Hoo ParkDepartment of Pathology, Korea Cancer Center Hospital, Seoul, Korea.
Kee-Ho LeeDivision of Radiation Cancer Research, Korea Institute of Radiological and Medication Sciences, Seoul, Korea.
Korea Institute of Radiological and Medical Sciences · KRDongnam Institute of Radiological & Medical Sciences · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDS/

aimsCysteine dioxygenase type 1 (

methodsUsing a HCC cell line (SNU423), an in vitro demethylation study was performed to confirm whether promoter methylation causes

results

conclusionsThese results suggested that methylation down-regulated

Indexed as

BiomarkerCysteine dioxygenase type 1DemethylationDNA methylationHepatocellular carcinoma

Identifiers

PMID29264579
PMCPMC5736736
OpenAlexW2777460739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.