Evidence map›Paper›PMID 29264545›Full record

ArticleJournal of the Endocrine Society2017

Characterization of Cortisol Secretion Rate in Secondary Adrenal Insufficiency.

Richard I Dorin, Zhi George Qiao, Matthew Bouchonville, Clifford R Qualls, Ronald M Schrader, Frank K Urban

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Adrenal Insufficiency in Cirrhosis.Journal of the Endocrine Society · 2022
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Richard I DorinMedical Service, New Mexico VA Healthcare System, University of New Mexico School of Medicine, Albuquerque, New Mexico 87108.
Zhi George QiaoDepartments of Medicine and Biochemistry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106.
Matthew BouchonvilleDepartments of Medicine and Biochemistry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87106.
Clifford R QuallsClinical and Translational Science Center, University of New Mexico, Albuquerque, New Mexico 87106.
Ronald M SchraderDialysis Clinic, Inc., Albuquerque, New Mexico 87102.
Frank K UrbanDepartment of Electrical and Computer Engineering, Florida International University, Miami, Florida 33174.
University of New Mexico · USFlorida International University · USNew Mexico VA Health Care System · USRadiology Associates of Albuquerque · US

Funding

University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
UNIVERSITY OF NEW MEXICO CLINICAL AND TRANSLATIONAL SCIENCE CENTERUL1RR031977 · NCRR · UNIVERSITY OF NEW MEXICO · PI LARSON, RICHARD S · 2010 to 2011
$8.8M
NCATS NIH HHS UL1 TR000041NCRR NIH HHS UL1 RR031977
6 · The paper itself

Abstract

contextIn secondary adrenal insufficiency (SAI), chronic deficiency of adrenocorticotropin (ACTH) is believed to result in secondary changes in adrenocortical function, causing an altered dose-response relationship between ACTH concentration and cortisol secretion rate (CSR).

objectiveWe sought to characterize maximal cortisol secretion rate (CSR

designCSR

settingSingle academic medical center. PATIENTS: Patients with SAI (n = 10) compared with age-matched healthy controls (n = 21).

interventionsThe order of DEX vs placebo pretreatment was randomized and double-blind. Cortisol concentrations were obtained at baseline and at intervals for 120 minutes after ACTH

main outcome measuresCSR

resultsCSR

conclusionsOur finding of significantly decreased CSR

Indexed as

adrenal insufficiencycomputer-assistedcosyntropinhydrocortisonemetabolic clearance ratemultivariable analysisnumerical analysis

Identifiers

PMID29264545
PMCPMC5686692
OpenAlexW2620768565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.