Evidence map›Paper›PMID 29264528›Full record

ArticleJournal of the Endocrine Society2017

Combined Hormonal Contraceptives and First Venous Thrombosis in Young French Women: Impact of Thrombotic Family History.

Justine Hugon-Rodin, Marie-Hélène Horellou, Jacqueline Conard, Anne Gompel, Geneviève Plu-Bureau

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Justine Hugon-RodinUniversity Paris-Saclay and Paris-Sud, UVSQ, CESP, U1018, INSERM, 94800 Villejuif, France.
Marie-Hélène HorellouHematology Biology Unit, Hôpital Universitaire Paris Centre, APHP, 75014 Paris, France.
Jacqueline ConardHematology Biology Unit, Hôpital Universitaire Paris Centre, APHP, 75014 Paris, France.
Anne GompelGynecology Endocrinology Unit, Hôpital Universitaire Paris Centre, APHP, 75014 Paris, France.
Geneviève Plu-BureauUniversity Paris-Saclay and Paris-Sud, UVSQ, CESP, U1018, INSERM, 94800 Villejuif, France.
Assistance Publique – Hôpitaux de Paris · FRDélégation Paris 5 · FRInserm · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextIn UK and French, but not World Health Organization (WHO), guidelines for combined hormonal contraception (CHC), family history of a venous thromboembolism (VTE) is a condition for which the theoretical risks usually outweigh the advantages of using CHC.

objectiveWe estimated the prevalence of inappropriate prescriptions of CHC according to several international guidelines and their impact on VTE.

designA single-center observational study.

settingHemostasis unit outpatient clinic (Paris, France). POPULATION: A total of 2088 French CHC users of childbearing age with a first documented VTE who were referred to our unit between 2000 and 2009.

methodsData were collected by a standardized questionnaire during a medical consultation. Family history of VTE was analyzed according to definitions from international recommendations (VTE before age 45 years, United Kingdom; before age 50 years, France). A CHC prescription was considered inappropriate for women with vascular contraindications and/or a family history of VTE. Cross-sectional analysis of the clinical and biological characteristics was performed.

main outcome measuresPrevalence of inappropriate prescription of CHC and potentially preventable events were estimated.

resultsAccording to the WHO, UK, or French guidelines, 8.8%, 18.9%, and 25.9%, respectively, of CHC prescriptions were considered inappropriate. Compliance with these guidelines could reduce the corresponding number of VTEs by 6.3%, 13.5%, and 18.5%, respectively. Characteristics of the women were similar.

conclusionOur results suggest inappropriate CHC prescriptions are prevalent among CHC users with first VTE. The appropriate way to take family history of VTE into account should be further clarified.

Indexed as

combined hormonal contraceptivefamily history of thrombosisinappropriate prescriptionpreventable casesrisk factors

Identifiers

PMID29264528
PMCPMC5686595
OpenAlexW2605760641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.