ArticleJournal of the Endocrine Society2017
Increased Adrenal Androgens in Overweight Peripubertal Girls.
Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Obesity Is Associated with Increased 11-Oxyandrogen Serum Concentrations during Puberty.Hormone research in paediatrics · 2026Article
- Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight.Journal of the Endocrine Society · 2025Article
- Article
- Evaluating the Arterial Stiffness as a Useful Tool in the Management of Obese Children.Children (Basel, Switzerland) · 2023Article
- The Oscillometric Pulse Wave Analysis Is Useful in Evaluating the Arterial Stiffness of Obese Children with Relevant Cardiometabolic Risks.Journal of clinical medicine · 2022Article
- 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2022Article
- Non-PCOS Hyperandrogenic Disorders in Adolescents.Seminars in reproductive medicine · 2022Article
- Polycystic Ovary Syndrome: Ontogeny in Adolescence.Endocrinology and metabolism clinics of North America · 2021Review
- Increased Arterial Stiffness in Adolescents With Obesity.Global pediatric health · 2019Article
- New perspectives on the definition and management of polycystic ovary syndrome.Journal of endocrinological investigation · 2018Review
- Progesterone Suppression of Luteinizing Hormone Pulse Frequency in Adolescent Girls With Hyperandrogenism: Effects of Metformin.The Journal of clinical endocrinology and metabolism · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
contextPeripubertal hyperandrogenemia-a precursor to polycystic ovary syndrome-is prominent in girls with obesity.
objectiveWe examined sources of overnight testosterone (T) and progesterone (P4) and potential sources of obesity-associated hyperandrogenemia during puberty.
designCross-sectional.
settingResearch unit. PARTICIPANTS/
interventionsFifty girls ages 7 to 18 years-both normal weight (NW) and overweight (OW)-underwent dexamethasone (DEX) suppression (1 mg orally; 10 pm) and cosyntropin stimulation testing (0.25 mg intravenously; 8 am the following day), with blood sampled before and 30 and 60 minutes after cosyntropin. Thirty-nine subjects receiving DEX had frequent blood sampling overnight (every 10 minutes from 10 pm to 7 am) and were compared with 70 historical controls who did not receive DEX. OUTCOMES: Random coefficient regression modeling assessed changes in hormone concentrations after DEX and cosyntropin.
resultsNW early pubertal controls exhibited early morning increases in free T and P4 levels; NW and OW late pubertal controls exhibited early morning increases in P4. Such changes were not observed in subjects receiving DEX. Post-DEX morning free T levels were fourfold higher in OW vs NW late pubertal girls. Postcosyntropin changes in free T and androstenedione were both 2.3-fold higher in OW vs NW late pubertal girls.
conclusionsThese data suggest that (1) overnight increases in free T and P4 concentrations in NW early pubertal girls and P4 concentrations in late pubertal girls are of adrenal origin and (2) OW late pubertal girls demonstrate elevated nonadrenal free T levels after DEX and exaggerated adrenal androgen (free T and androstenedione) responses to cosyntropin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.