ArticleJournal of the Endocrine Society2017
Successful Pregnancies After Adequate Hormonal Replacement in Patients With Combined Pituitary Hormone Deficiencies.
Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Breastfeeding in panhypopituitarism: a case report, review of the literature, and management checklist.International breastfeeding journal · 2026Review
- Review
- Oxytocin: a neglected hormone in pituitary disease - From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology.Archives of endocrinology and metabolism · 2025Review
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency.Nature reviews. Endocrinology · 2024Review
- Fertility issues in hypopituitarism.Reviews in endocrine & metabolic disorders · 2024Review
- Article
- Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy.Endocrine connections · 2022Article
- Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome.Pituitary · 2022Article
- Observational
- Fertility issues in aggressive pituitary tumors.Reviews in endocrine & metabolic disorders · 2020Review
- Management of Hypopituitarism.Journal of clinical medicine · 2019Review
- Growth Hormone and Reproduction: Lessons Learned From Animal Models and Clinical Trials.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextWomen with hypopituitarism have lower pregnancy rates after ovulation induction. Associated pituitary hormone deficiencies might play a role in this poorer outcome.
objectiveWe evaluated fertility treatment and pregnancy outcomes in five women with childhood-onset combined pituitary hormone deficiencies (CPHD). PATIENTS AND
methodsFive women with CPHD were referred for fertility treatment after adequacy of hormone replacement was determined. Patients were subjected to controlled ovarian stimulation (COS) for timed intercourse, intrauterine insemination, or
resultsAll women became pregnant. The number of COS attempts until pregnancy was achieved varied between 1 and 5. The duration of COS resulting in at least one dominant follicle varied between 9 and 28 days, and total gonadotropin consumed varied between 1200 and 3450 IU. Two patients with severely suppressed basal gonadotropin levels since an early age had a cancelled COS cycle. All pregnancies were singleton except one (monochorionic twin gestation). The gestational ages at birth ranged from 35 weeks to 39 weeks and 4 days; three patients underwent cesarean section, and two had vaginal deliveries. Only one newborn was small for gestational age (delivered at 35 weeks).
conclusionAdequate hormonal replacement prior to ovarian stimulation resulted in successful pregnancies in patients with childhood-onset CPHD, indicating that hormone replacement, including growth hormone, is an important step prior to fertility treatments in these patients.
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