ArticleJournal of the Endocrine Society2017
Fat-Bone Interactions in Adults With Spina Bifida.
Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Understanding Orthopaedic and Health-related Quality of Life Outcomes in Patients With Myelomeningocele Functional Classification 1 Spina Bifida in Relationship to Supportive Standing.Journal of the Pediatric Orthopaedic Society of North America · 2025Article
- Application of Bioelectrical Impedance Analysis in Weight Management of Children with Spina Bifida.Nutrients · 2024Article
- Impairments and comorbidities in adults with cerebral palsy and spina bifida: a meta-analysis.Frontiers in neurology · 2023Review
- Musculoskeletal Morbidity Among Adults Living With Spina Bifida and Cerebral Palsy.Topics in spinal cord injury rehabilitation · 2022Article
- Psychological morbidity among adults with cerebral palsy and spina bifida.Psychological medicine · 2021Article
- Evaluation of Pain in Adults With Childhood-Onset Disabilities and Communication Difficulties.Frontiers in neurology · 2021Review
- Cardiometabolic Morbidity in Adults With Cerebral Palsy and Spina Bifida.The American journal of medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSpina bifida (SB) can lead to changes in body composition and bone mineral density (BMD) through diminished ambulation, renal impairment, and anticonvulsant medication. With increased life expectancy, diseases such as obesity and osteoporosis are emerging comorbidities in SB, with limited data to guide management.
objectiveTo examine the relationship between cardiometabolic factors, body composition, BMD, and minimal trauma fractures (MTFs) in adults with SB.
designRetrospective cross-sectional study. SETTING AND
participantsForty-nine adults with SB (median age, 32.7 years; interquartile range, 22.6 to 39.0) who had undergone dual-energy x-ray absorptiometry imaging at a single tertiary hospital from 2004 to 2015.
resultsThe mean body mass index was 31.7 ± 7.5 kg/m2; 26 (53.1%) were obese. Using age- and sex-matched fat percentiles from the National Health and Nutrition Examination Survey III, 62.5% had a total body percentage fat greater than the 95th percentile. Low bone mass (defined as a Z-score of ≤-2.0) was present in 21.9% at the L1 vertebra and in 35.1% at the femoral neck. Ten (20.4%) had a history of MTFs. A BMD or Z-score at L1, femoral neck, or total body site did not correlate with the occurrence of MTF. Fat mass was significantly and positively associated with BMD after adjustment for age, sex, and height and accounted for 18.6% of the variance in BMD (
conclusionsObesity and low BMD are common in young adults with SB. An increased fat mass correlated significantly with BMD. The prevalence of metabolic complications in patients with SB is increased and deserves further study.
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