ArticleJournal of the Endocrine Society2017
Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women.
Article in Journal of the Endocrine Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.Science translational medicine · 2020Pooled it
- Secreted frizzled-related protein 3 is associated with metabolic disturbances in gestational diabetes.Frontiers in endocrinology · 2026Article
- Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease.International journal of molecular sciences · 2024Article
- Article
- The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification.Inflammation · 2021Review
- Cruciferous vegetable intake is inversely associated with extensive abdominal aortic calcification in elderly women: a cross-sectional study.The British journal of nutrition · 2021Article
- Abdominal aortic calcification, bone mineral density and fractures: a systematic review and meta-analysis protocol.BMJ open · 2019Article
- Glycemic variability is associated with vascular calcification by the markers of endoplasmic reticulum stress-related apoptosis, Wnt1, galectin-3 and BMP-2.Diabetology & metabolic syndrome · 2019Article
- Clinical advantages and disadvantages of anabolic bone therapies targeting the WNT pathway.Nature reviews. Endocrinology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 6 countries.
Funding
Abstract
contextThere is great interest in the biology of vascular calcification. Wnt/
objectiveWe assessed the association between circulating Wnt antagonists and abdominal aortic calcification (AAC) severity in elderly women.
designThis was a cross-sectional analysis of the Calcium Intake Fracture Outcome Study.
settingThe participants were recruited from the community-dwelling elderly population.
participantsWe examined 768 women aged over 70 years.
interventionsWe collected blood samples, and lateral spine images captured during bone density assessment were used to score AAC with a validated 24-point scale.
main outcome measuresWe tested the hypothesis that low Wnt antagonist levels of Dickkopf-1 (DKK1), secreted frizzled related protein 3 (sFRP3), and Wnt inhibitory factor 1 (WIF1) are associated with severe AAC (AAC24 score > 5).
resultsSevere AAC was present in 146 women (19%). Lower levels of DKK1, but not WIF1 and sFRP3, were associated with higher odds of severe AAC. Per standard deviation decrease in DKK1 was associated with increased multivariable-adjusted odds ratio (OR) of severe AAC [OR, 1.26; 95% confidence interval (CI), 1.04 to 1.52;
conclusionsIn elderly women, DKK1, but not sFRP3 or WIF1, is associated with severe AAC. This study supports the concept that Wnt/
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