Evidence map›Paper›PMID 29264355›Full record

ArticleGerms2017

Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaoundé, Cameroon.

George Mondinde Ikomey, Marie Claire Okomo Assoumou, Josiah Otwoma Gichana, Duncan Njenda, Sello Given Mikasi, Martha Mesembe, Emilia Lyonga, Graeme Brendon Jacobs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

George Mondinde IkomeyPhD, Center for the Study and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO Box 8445, Yaoundé, Cameroon.
Marie Claire Okomo AssoumouPhD, Center for the Study and Control of Communicable Diseases (CSCCD) Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO Box 8445, Yaoundé, Cameroon.
Josiah Otwoma GichanaBSc, Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Tygerberg 7505, South Africa.
Duncan NjendaMSc, Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Tygerberg 7505, South Africa.
Sello Given MikasiMSc, Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Tygerberg 7505, South Africa.
Martha MesembeBSc, Center for the Study and Control of Communicable Diseases (CSCCD) Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO Box 8445, Yaoundé, Cameroon.
Emilia LyongaMSc, Center for the Study and Control of Communicable Diseases (CSCCD) Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO Box 8445, Yaoundé, Cameroon.
Graeme Brendon JacobsPhD, Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Tygerberg 7505, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe emergence of drug resistance mutations (DRMs) has been a major threat for successful lifelong combination antiretroviral therapy (cART), especially for HIV-vertically infected children within the context of the prevention of mother-to-child transmission (PMTCT). This study aimed to evaluate DRMs amongst immune competent treatment-naïve children in Cameroon.

methodsA cross-sectional study was conducted between 2015 and 2016 amongst 55 proxy consented HIV-1 positive children, aged 9 months to 6 years. They were all immune competent, cART naïve and with unknown history of PMTCT. CD4 cell counts and genotypic drug resistance testing were performed using standard methods.

resultsLevels of DRMs to protease (PR) inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs) and non-NRTIs were 27.6%, 3.7% and 40.7%, respectively. Only minor DRMs were observed for PR. The observed mutations for NRTI were K65R, T215I and K219E (33.0% each) and for NNRTI: V106M, Y181C and Y188H (6.0% each). Only minor accessory mutations were found in the integrase (IN) region.

conclusionDespite widely available cART we still observe naïve HIV children, especially from the rural communities. We observe that a proportion of study participants had HIV-1 drug resistance associated mutations (RAMs). Data generated could help strengthen the current PMTCT programmes within the country. There is a need to upscale approaches for drug resistance testing for children in Cameroon and many other resource-limited settings.

Indexed as

CameroonHIVimmune competentinfantsprevention of mother-to-child-transmission (PMTCT)resistancetreatment-naïve

Identifiers

PMID29264355
PMCPMC5734927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.