Evidence map›Paper›PMID 29264284›Full record

ArticleAnnals of maxillofacial surgery

Lugol Chromoscopy in the Follow-up of Head and Neck Carcinoma.

Cesar Augusto Simões, Marcelo Doria Durazzo, Flávia Caló de Aquino Xavier, Marina Helena Cury Gallottini, Sílvia Vanessa Lourenço, Décio Dos Santos Pinto Júnior, Natália Martins Magacho de Andrade, Aline Paterno Miazaki, Rogério Aparecido Dedivitis, Cláudio Roberto Cernea

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Article in Annals of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Use of Fluorescent Markers to Detect and Delineate Head and Neck Cancer: A Scoping Review.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cesar Augusto SimõesDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Marcelo Doria DurazzoDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Flávia Caló de Aquino XavierDepartment of Stomatology, University of São Paulo Dental School, São Paulo, Brazil.
Marina Helena Cury GallottiniDepartment of Stomatology, University of São Paulo Dental School, São Paulo, Brazil.
Sílvia Vanessa LourençoDepartment of Stomatology, University of São Paulo Dental School, São Paulo, Brazil.
Décio Dos Santos Pinto JúniorDepartment of Stomatology, University of São Paulo Dental School, São Paulo, Brazil.
Natália Martins Magacho de AndradeDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Aline Paterno MiazakiDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Rogério Aparecido DedivitisDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Cláudio Roberto CerneaDepartment of Head and Neck Surgery, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLugol is helpful in identifying early second primary tumors (SPTs) during oroscopy and pharyngoscopy, but this technique has not been assessed during follow-up visits with these patients.

aimThe aim of this study is to describe the use of Lugol (a low-cost method) to diagnose SPTs in the oral cavity and oropharynx.

methodsPatients treated for squamous cell carcinoma of the head and neck were randomly assigned to two groups. Group A was examined with routine oroscopy and pharyngoscopy without Lugol, and Group B was examined with routine oroscopy and pharyngoscopy without stain and with Lugol. A total of 211 patients were included during 4 years.

resultsSix oral and oropharynx carcinomas were detected in Group A. Eighteen oral and oropharynx carcinomas were detected in Group B, twelve of which were not seen without chromoscopy but were detected with Lugol.

conclusionLugol increases the detection of malignant lesions compared to routine examination alone.

Indexed as

Coloring agentslow-cost diagnosticLugolmouth neoplasmsprospective studiessquamous cell carcinoma

Identifiers

PMID29264284
PMCPMC5717893

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