ArticlePlastic and reconstructive surgery. Global open2017
Genetic Overview of Syndactyly and Polydactyly.
Article in Plastic and reconstructive surgery. Global open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.BMC medical genomics · 2026Article
- L-type voltage-gated CaEMBO reports · 2026Article
- Anatomical Variations in Bilateral Hand Oligodactyly: A Case Analysis of Cleft Hand.Diagnostics (Basel, Switzerland) · 2026Article
- Polydactyly and syndactyly in a Chinese family with Floating-Harbor syndrome: an expansion of the clinical phenotype.Frontiers in genetics · 2026Article
- Surgical Approaches and Outcomes for 69 First Web Space Congenital Syndactyly Cases of the Hand.Journal of hand surgery global online · 2025Article
- NovelGenes · 2025Article
- Ulnar polydactyly of the hand: a classification system and clinical series.BMC musculoskeletal disorders · 2025Article
- Review
- Polydactyly and syndactyly linked to GLI3 and TBX5 mutations: A pediatric case report.Global medical genetics · 2025Article
- Phenotype-to-Genotype Description of Prenatal Suspected and Postnatal Discovered Upper Limb Anomalies: A Retrospective Cohort Study.Prenatal diagnosis · 2025Article
- A novel missense variant located within the zinc finger domain of the GLI3 gene was identified in a Vietnamese pedigree with index finger polydactyly.Molecular genetics & genomic medicine · 2024Article
- Chronic Overlapping Pain Conditions and Nociplastic Pain.medRxiv : the preprint server for health sciences · 2024Article
- A novelHeliyon · 2024Article
- Postaxial polydactyly: A case report highlighting genetic context, epidemiological trends, and management options.SAGE open medical case reports · 2024Article
- Postaxial polydactyly of the bilateral hand in toddler: Case report and literature review.SAGE open medical case reports · 2024Article
- Sequence Variants inMolecular syndromology · 2023Article
- The changing epidemiology of syndactyly in Chinese newborns: a nationwide surveillance-based study.BMC pregnancy and childbirth · 2023Article
- Keeping you on your toes: Smith-Lemli-Opitz Syndrome is an easily missed cause of developmental delays.Clinical case reports · 2023Article
- Identification of a HOXD13 variant in a Mongolian family with incomplete penetrance syndactyly by exon sequencing.BMC medical genomics · 2022Article
- Genetic determinants of syndactyly: perspectives on pathogenesis and diagnosis.Orphanet journal of rare diseases · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syndactyly and polydactyly-respectively characterized by fused and supernumerary digits-are among the most common congenital limb malformations, with syndactyly presenting at an estimated incidence of 1 in 2,000-3,000 live births and polydactyly at a frequency of 1 in approximately 700-1,000 live births. Despite their relatively regular manifestation in the clinic, the etiologies of syndactyly and polydactyly remain poorly understood because of their phenotypic and genetic diversity. Further, even though concrete knowledge of genotypic links has been established for some variants of syndactyly and polydactyly, there appears to be no single comprehensive published summary of all syndromic and nonsyndromic syndactyly and polydactyly presentations, and there is decidedly no resource that maps all syndromic and nonsyndromic syndactylies and polydactylies to their genetic bases. This gap in the literature problematizes comprehensive carrier screening and prenatal diagnosis and complicates novel diagnostic attempts. This review thus attempts to collect all that is known about the genetic bases of syndromic and nonsyndromic syndactylies and polydactylies, as well as to highlight the dactyly manifestations for which no genetic bases are as yet known. Then, having established a summation of existing and missing knowledge, this work briefly outlines the diagnostic techniques that a genetics-reinforced understanding of syndactyly and polydactyly could inform.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.