Evidence map›Paper›PMID 29263879›Full record

ArticleNPJ vaccines2017

Protein nanovaccine confers robust immunity against

Kamal El Bissati, Ying Zhou, Sara Maria Paulillo, Senthil Kumar Raman, Christopher P Karch, Craig W Roberts, David E Lanar, Steve Reed, Chris Fox, Darrick Carter and 7 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. CD4Vaccines · 2023
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Advances inVaccines · 2021
    Review
  19. Development of vaccine formulations: past, present, and future.Drug delivery and translational research · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Kamal El BissatiDepartments of OVS, The University of Chicago, 5841S Maryland Ave, Chicago, IL 60637 USA.
Ying ZhouDepartments of OVS, The University of Chicago, 5841S Maryland Ave, Chicago, IL 60637 USA.
Sara Maria PaulilloAlpha-O Peptides AG, Lörracherstrasse 50, 4125 Riehen, Switzerland.
Senthil Kumar RamanAlpha-O Peptides AG, Lörracherstrasse 50, 4125 Riehen, Switzerland.
Christopher P KarchInstitute of Materials Science and Department of Molecular and Cell Biology, University of Connecticut, 97 North Eagleville Road, Storrs, CT 06269 USA.
Craig W RobertsStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE UK.ORCID 0000-0002-0653-835X
David E LanarWalter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
Steve ReedInfectious Diseases Research Institute, 1616 Eastlake Ave E #400, Seattle, WA 98102 USA.
Chris FoxInfectious Diseases Research Institute, 1616 Eastlake Ave E #400, Seattle, WA 98102 USA.
Darrick CarterInfectious Diseases Research Institute, 1616 Eastlake Ave E #400, Seattle, WA 98102 USA.ORCID 0000-0001-5901-3402
Jeff AlexanderPaxVax, 3985-A Sorrento Valley Blvd, San Diego, CA 92121 USA.
Alessandro SetteLa Jolla Institute of Allergy and Immunology, 9420 Athena Cir, La Jolla, CA 92037 USA.
John SidneyLa Jolla Institute of Allergy and Immunology, 9420 Athena Cir, La Jolla, CA 92037 USA.
Hernan LorenziJ. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850 USA.
Ian J BegemanDepartments of OVS, The University of Chicago, 5841S Maryland Ave, Chicago, IL 60637 USA.
Peter BurkhardAlpha-O Peptides AG, Lörracherstrasse 50, 4125 Riehen, Switzerland.
Rima McLeodDepartments of OVS, The University of Chicago, 5841S Maryland Ave, Chicago, IL 60637 USA.
University of Chicago · USInfectious Disease Research Institute · USLa Jolla Institute for Immunology · USUniversity of Connecticut · USJ. Craig Venter Institute · USPaxVax (United States) · USUniversity of Strathclyde · GBWalter Reed Army Institute of Research · US

Funding

The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI SUTTON, GRANGER GIDEON · 2014 to 2018
$29.7M
Towards a Vaccine to Prevent ToxoplasmosisU01AI077887 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 2008 to 2012
$4.2M
TREATMENT OF CONGENITAL TOXOPLASMOSISR01AI027530 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 1989 to 2010
$2.8M
NIAID NIH HHS R01 AI027530NIAID NIH HHS U01 AI077887NIAID NIH HHS U19 AI110819
6 · The paper itself

Abstract

We designed and produced a self-assembling protein nanoparticle. This self-assembling protein nanoparticle contains five CD8

Identifiers

PMID29263879
PMCPMC5627305
OpenAlexW2745945696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.