Evidence map›Paper›PMID 29263876›Full record

ArticleNPJ vaccines2017

A VLP-based vaccine provides complete protection against Nipah virus challenge following multiple-dose or single-dose vaccination schedules in a hamster model.

Pramila Walpita, Yu Cong, Peter B Jahrling, Oscar Rojas, Elena Postnikova, Shuiqing Yu, Lisa Johns, Michael R Holbrook

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Nipah virus: a summary for clinicians.International journal of emergency medicine · 2025
    Review
  10. Nipah virus: pathogenesis, genome, diagnosis, and treatment.Applied microbiology and biotechnology · 2025
    Review
  11. Review
  12. Promising Vaccine Formulations for Emerging Infectious Diseases.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pramila Walpita *School of Medicine, University of Hawaii, Manoa, Honolulu, HI USA.
Yu Cong *National Institute of Allergy and Infectious Diseases, Integrated Research Facility, Fort Detrick, Frederick, MD 21702 USA.
Peter B JahrlingSchool of Medicine, University of Hawaii, Manoa, Honolulu, HI USA.
Oscar RojasNational Institute of Allergy and Infectious Diseases, Integrated Research Facility, Fort Detrick, Frederick, MD 21702 USA.
Elena PostnikovaNational Institute of Allergy and Infectious Diseases, Integrated Research Facility, Fort Detrick, Frederick, MD 21702 USA.
Shuiqing YuSchool of Medicine, University of Hawaii, Manoa, Honolulu, HI USA.
Lisa JohnsSchool of Medicine, University of Hawaii, Manoa, Honolulu, HI USA.
Michael R HolbrookNational Institute of Allergy and Infectious Diseases, Integrated Research Facility, Fort Detrick, Frederick, MD 21702 USA.ORCID 0000-0002-0824-2667
National Institute of Allergy and Infectious Diseases · USUniversity of Hawaiʻi at Mānoa · US

Funding

Integrated Research Facility at Fort DetrickZIDAI009006 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI COE, LINDA · 2009 to 2018
$341.7M
Vaccine Potential of Nipah virus-like ParticlesR01AI095464 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WALPITA, PRAMILA NONE · 2012 to 2014
$1.1M
NIAID NIH HHS HHSN272200700016INIAID NIH HHS R01 AI095464
6 · The paper itself

Abstract

Nipah virus is a highly lethal zoonotic paramyxovirus that was first recognized in Malaysia during an outbreak in 1998. During this outbreak, Nipah virus infection caused a severe febrile neurological disease in humans who worked in close contact with infected pigs. The case fatality rate in humans was approximately 40%. Since 2001, NiV has re-emerged in Bangladesh and India where fruit bats (

Identifiers

PMID29263876
PMCPMC5627259
OpenAlexW2735923367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.