ArticleNPJ genomic medicine2017
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.
Article in NPJ genomic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis.Disease markers · 2022Pooled it
- Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology · 2021Pooled it
- Polypharmacy in outpatients with relapsing-remitting multiple sclerosis: A single-center study.PloS one · 2019Trial
- Article
- Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study.Pediatric rheumatology online journal · 2024Article
- Article
- Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization.Scientific reports · 2024Article
- Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives.Clinical and experimental medicine · 2023Review
- Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin.Nature genetics · 2023Article
- Observational
- Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.Science advances · 2022Article
- Usefulness of Clinical and Laboratory Criteria for Diagnosing Autoimmune Liver Disease among Patients with Systemic Lupus Erythematosus: An Observational Study.Journal of clinical medicine · 2021Article
- Improvement of Comorbid Psoriasis in Patients With MS Treated With Natalizumab.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Concurrence of multiple sclerosis and primary biliary cholangitis: Report of 3 cases.Caspian journal of internal medicine · 2020Article
- Multi-drug use among patients with multiple sclerosis: A cross-sectional study of associations to clinicodemographic factors.Scientific reports · 2019Article
- DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors at 12 institutions in 4 countries.
Funding
Abstract
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.