ArticleNPJ genomic medicine2017
Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies.
Article in NPJ genomic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.Nature communications · 2020Pooled it
- Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbAScientific reports · 2017Pooled it
- Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model.bioRxiv : the preprint server for biology · 2026Article
- Systematic investigation of interindividual variation of DNA methylation in human whole blood.Genome biology · 2026Article
- A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest.Genome research · 2026Review
- Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort.Frontiers in genetics · 2026Article
- Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity.Epigenomics · 2026Article
- Exploring novel blood-based DNA methylation biomarkers for alzheimer's disease via targeted sequencing of highly variable CpG sites.BMC research notes · 2025Article
- Epigenetic regulation of the humanBiochemistry and biophysics reports · 2024Article
- Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS).Journal of epidemiology · 2024Article
- Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.Journal of biochemistry · 2024Article
- Predicting locus-specific DNA methylation levels in cancer and paracancer tissues.Epigenomics · 2024Article
- Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population.Diabetology international · 2023Article
- Article
- SNP-by-CpG Site Interactions inGenes · 2022Article
- Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.iScience · 2022Article
- Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics.Clinical epigenetics · 2021Article
- Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking.Clinical epigenetics · 2021Article
- Article
- Dynamic DNA Methylation Changes in theBiomolecules · 2021Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenome-wide association studies, which searches for blood-based DNA methylation signatures associated with environmental exposures and/or disease susceptibilities, is a promising approach to a better understanding of the molecular aetiology of common diseases. To carry out large-scale epigenome-wide association studies while avoiding false negative detection, an efficient strategy to determine target CpG sites for microarray-based or sequencing-based DNA methylation profiling is essentially needed. Here, we propose and validate a hypothesis that a strategy focusing on CpG sites with high DNA methylation level variability may attain an improved efficacy. Through whole-genome bisulfite sequencing of purified blood cells collected from > 100 apparently healthy subjects, we identified ~2.0 million inter-individually variable CpG sites as potential targets. The efficacy of our strategy was estimated to be 3.7-fold higher than that of the most frequently used strategy. Our catalogue of inter-individually variable CpG sites will accelerate the discovery of clinically relevant DNA methylation biomarkers in future epigenome-wide association studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.